Deficiency of Parkinson's disease-related gene Fbxo7 is associated with impaired mitochondrial metabolism by PARP activation.
Cell Death Differ.2017 Jan;24(1):120-131. Epub 2016 Sep 30
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摘要
content and redox index and ATP pool, suggesting that overactivation is cause of decreased complex I-driven respiration. These findings bring new insight into the mechanism of Fbxo7 deficiency, emphasising the importance of mitochondrial dysfunction in PD.
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基因功能
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原始数据
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文献解读
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