| Type | Description |
|---|---|
| Definition | guanylate cyclase activator 2A |
| Date | Results | Publications |
|---|---|---|
| 2018-08-04 12:01:00 | These results support the hypothesis that IL-15 secreted from Gn-GC-C-expressing macrophages contributes to the inhibition of fatty acid synthase and lipid accumulation in adipocytes, leading to obesity resistance | 29097254 |
| 2017-05-20 12:02:00 | The specific cellular distribution of both GN and UGN differs between duodenum and colon and between human and rat intestines. | 27044258 |
| 2016-08-20 12:24:00 | Data (including data from studies in transgenic rats) suggest guanylin--guanylyl cyclase-C signaling in macrophages in mesenteric fat regulates cGMP--PKG--VASP pathway and mesenteric panniculitis/obesity via down-regulation of proinflammatory factors. | 26249840 |
| 2013-06-01 11:47:00 | the macrophagic guanylin-GC-C system contributes to the altered expression of genes involved in lipid metabolism, leading to resistance to obesity | 23081987 |
| 2013-02-09 11:31:00 | guanylin is synthesized as an intrinsic peptide in epithelial cells of the hepatobiliary system and released luminally into the hepatic and cystic bile to regulate electrolyte secretion by a paracrine/luminocrine signaling pathway | 22310983 |
| Type | IDs |
|---|---|
| Synonymous | GUANYL, Guanylin, Guca2 |
| Gene |
UniProtKB-ID:
GUC2A_RAT
UniprotKB:
P28902
UniParc:
UPI000012BD8A
EMBL:
M93005,
X67669,
M95493
Ensembl:
ENSRNOG00000008849
KO:
rno:25656
|
| Nucleutide sequences |
EMBL-CDS:
AAA41300.1,
CAA47901.1,
AAA41302.1
Ensembl_TRS:
ENSRNOT00000011867
|
| Protein sequencees |
Ensembl_PRO:
ENSRNOP00000011867
RefSeq:
NP_037250.1
|
| Others |
UniRef100:
UniRef100_P28902
UniRef90:
UniRef90_P28902
UniRef50:
UniRef50_P28902
UniGene:
Rn.11388
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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