Parp1 - poly (ADP-ribose) polymerase 1-BMKCloudï½ç¾è¿å®¢äº

例如："NBL1", "4681", "drought"

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25591 Parp1

基因描述

Type	Description
Definition	poly (ADP-ribose) polymerase 1

研究结论

Date	Results	Publications
2021-02-20 13:28:00	SIRT3 inhibits cardiac hypertrophy by regulating activity.	32139662
2020-06-20 11:21:00	These results provide novel and compelling evidence that exacerbated cardiac fibrosis, which was partially attributed to NAD-dependent activation of mTOR.	29278652
2020-01-18 12:22:00	Authors identified that when combining with Cul4a could reduce its expression, and the interaction was enhanced under oxidative stress.	31178959
2019-12-14 12:17:00	The data indicate that poly(ADP-ribosyl)ation of FoxO3a plays a key role in cardiomyocyte autophagy.	30323296
2019-08-03 10:32:00	Overexpressed binds and PARylates HMGB1. Subsequent nuclear export of HMGB1 in cardiomyocytes leads to cardiac hypertrophy.	30030529

名称对应

Type	IDs
Synonymous	ARTD1, Adprt, Parp-1
Gene	UniProtKB-ID: PARP1_RAT UniprotKB: P27008 UniParc: UPI0000167A42 EMBL: U94340, BC085765, X65496, X65497 Ensembl: ENSRNOG00000003084 KO: rno:25591
Nucleutide sequences	EMBL-CDS: CAA46477.1, AAC53544.1, AAH85765.1, CAA46478.1 Ensembl_TRS: ENSRNOT00000004232
Protein sequencees	Ensembl_PRO: ENSRNOP00000004232 RefSeq: NP_037195.1
Others	UniRef100: UniRef100_P27008 UniRef90: UniRef90_P27008 UniRef50: UniRef50_P09874 UniGene: Rn.11327

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mRNA

Protein

UniprotKB

Description

Refseq

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Pubmed编号	文献信息	发表日期	相关基因
32139900	Selective targeting of ubiquitination and degradation of PARP1 by E3 ubiquitin ligase WWP2 regulates isoproterenol-induced cardiac remodeling. Cell Death Differ Naijin Zhang , Ying Zhang , Hao Qian , Shaojun Wu , Liu Cao , Yingxian Sun	2020-09-01	-
32139662	SIRT3 inhibits cardiac hypertrophy by regulating PARP-1 activity. Aging (Albany NY) Xiaojun Feng , Yanan Wang , Wenxu Chen , Suowen Xu , Lingli Li , Yadi Geng , Aizong Shen , Hui Gao , Lei Zhang , Sheng Liu	2020-03-04	-
30030529	PARP1 interacts with HMGB1 and promotes its nuclear export in pathological myocardial hypertrophy. Acta Pharmacol. Sin. Qian Li , Zhuo-Ming Li , Shu-Ya Sun , Lu-Ping Wang , Pan-Xia Wang , Zhen Guo , Han-Wei Yang , Jian-Tao Ye , Jing Lu , Pei-Qing Liu	2019-05-01	-
29278652	Poly(ADP-ribose) polymerase 1 induces cardiac fibrosis by mediating mammalian target of rapamycin activity. J. Cell. Biochem. Shuya Sun , Yuehuai Hu , Qiyao Zheng , Zhen Guo , Duanping Sun , Shaorui Chen , Yiqiang Zhang , Peiqing Liu , Jing Lu , Jianmin Jiang	2019-04-01	-
30898999	DNA damage-induced PARP1 activation confers cardiomyocyte dysfunction through NAD⁺ depletion in experimental atrial fibrillation. Nat Commun Deli Zhang , Xu Hu , Jin Li , Jia Liu , LuciÃ«nne Baks-Te Bulte , Marit Wiersma , Noor-Ul-Ann Malik , Denise M S van Marion , Marziyeh Tolouee , Femke Hoogstra-Berends , Eva A H Lanters , Arie M van Roon , Antoine A F de Vries , DaniÃ«l A Pijnappels , Natasja M S de Groot , Robert H Henning , Bianca J J M Brundel	2019-03-21	-
31178959	Cul4a as a New Interaction Protein of PARP1 Inhibits Oxidative Stress-Induced H9c2 Cell Apoptosis. Oxid Med Cell Longev Ning Ye , Naijin Zhang , Ying Zhang , Hao Qian , Boquan Wu , Yingxian Sun	2019-01-01	-
30356214	Nuclear cGAS suppresses DNA repair and promotes tumorigenesis. Nature Haipeng Liu , Haiping Zhang , Xiangyang Wu , Dapeng Ma , Juehui Wu , Lin Wang , Yan Jiang , Yiyan Fei , Chenggang Zhu , Rong Tan , Peter Jungblut , Gang Pei , Anca Dorhoi , Qiaoling Yan , Fan Zhang , Ruijuan Zheng , Siyu Liu , Haijiao Liang , Zhonghua Liu , Hua Yang , Jianxia Chen , Peng Wang , Tianqi Tang , Wenxia Peng , Zhangsen Hu , Zhu Xu , Xiaochen Huang , Jie Wang , Haohao Li , Yilong Zhou , Feng Liu , Dapeng Yan , Stefan H E Kaufmann , Chang Chen , Zhiyong Mao , Baoxue Ge	2018-11-01	-
30323296	PARP1 promote autophagy in cardiomyocytes via modulating FoxO3a transcription. Cell Death Dis Cheng Wang , Wenjing Xu , Yanqing Zhang , Fengxiao Zhang , Kai Huang	2018-10-15	-
29501586	PARP1 interacts with STAT3 and retains active phosphorylated-STAT3 in nucleus during pathological myocardial hypertrophy. Mol. Cell. Endocrinol. Luping Wang , Zhuoming Li , Yinzi Tan , Qian Li , Hanwei Yang , Panxia Wang , Jing Lu , Peiqing Liu	2018-10-15	-
29608885	MicroRNA-223 protects neonatal rat cardiomyocytes and H9c2 cells from hypoxia-induced apoptosis and excessive autophagy via the Akt/mTOR pathway by targeting PARP-1. J Mol Cell Cardiol Xiaoxiao Liu , Yunfei Deng , Yifeng Xu , Wei Jin , Hongli Li	2018-05-01	-

研究热度

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