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25407 Cd59

25407

Cd59

CD59 molecule

protein-coding

Rattus norvegicus

基因描述

Type Description
Definition CD59 molecule

研究结论

Date Results Publications
2021-01-09 13:31:00 Coenzyme Q10 attenuates rat hepatocarcinogenesis via the reduction of CD59 expression and phospholipase D activity. 31989689
2020-05-30 12:01:00 study thus proposes the previously undescribed existence of non-GPI-anchored cytosolic CD59, which is required for insulin secretion. 31412214
2017-12-23 12:07:00 Study generated CD59(-/-) rats to investigate the role of CD59 in neuromyelitis optica spectrum disorders (NMO) and to create NMO pathology by passive transfer of AQP4-IgG. Results implicate an important role of CD59 in modulating NMO pathology in rats and demonstrate amplification of AQP4-IgG-induced NMO disease with CD59 knockout. 28212662
2017-12-23 12:06:00 Organ injury in neuromyelitis optica (NMO) seropositive CD59(-/-) rats was prevented by a complement inhibitor. Significant pathological changes in seropositive CD59(-/-) rats were not seen in optic nerve, spinal cord or brain, including circumventricular tissue. Results implicate a major protective role of CD59 outside of the central nervous system in seropositive NMO. 28750658
2010-01-21 00:00:00 In rats, CD59 and DAF genes are related to the negative effect of sulfasalazine on sperm maturation. 17166698

名称对应

Type IDs
Synonymous Cd59a, Cd59b, MAC-IP, MACIF, MACIP
Gene
UniProtKB-ID: CD59_RAT
UniprotKB: P27274
UniParc: UPI0000127389
EMBL: BC063176, U48255
Ensembl: ENSRNOG00000042821
KO: rno:25407
Nucleutide sequences
EMBL-CDS: AAA88909.1, AAH63176.1
Ensembl_TRS: ENSRNOT00000067085
Protein sequencees
Ensembl_PRO: ENSRNOP00000060967
RefSeq: NP_037057.1
Others
UniRef100: UniRef100_P27274
UniRef90: UniRef90_P27274
UniRef50: UniRef50_P27274
UniGene: Rn.1231

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