| Type | Description |
|---|---|
| Definition | guanidinoacetate N-methyltransferase |
| Date | Results | Publications |
|---|---|---|
| 2016-03-05 11:06:00 | 3D organotypic brain cell cultures showed that GAMT deficiency with significant residual enzymatic activity does not lead to creatine deficiency but generates sufficient guanidinoacetate to irreversibly affect developing brain | 25896543 |
| 2010-01-21 00:00:00 | x-ray crstallography studies explain why the Y136F mutant enzyme retains considerable catalytic activity while the Y136V mutant enzyme loses the catalytic activity. | 12925789 |
| 2010-01-21 00:00:00 | Crystal structure of guanidinoacetate methyltransferase from rat liver | 12079381 |
| 2010-01-21 00:00:00 | On the basis of the crystal structure of GAMT-S-adenosyl-L-homocysteine (SAH)+ guanidinoacetate (GAA) and the model structure of GAMT-S-adenosylmethionine (SAM)+ GAA, a possible catalytic mechanism of the methyl transfer reaction of GAMT is proposed. | 15533043 |
| 2010-01-21 00:00:00 | results suggest that de novo synthesis of creatine(Cr) by AGAT and GAMT, as well as cellular Cr uptake by CT1, are essential during embryonic development | 15918910 |
| Type | IDs |
|---|---|
| Synonymous | GMT |
| Gene |
UniProtKB-ID:
G3V960_RAT
UniprotKB:
G3V960
UniParc:
UPI000025110C
EMBL:
CH474029,
AC141331
Ensembl:
ENSRNOG00000024577
KO:
rno:25257
|
| Nucleutide sequences |
EMBL-CDS:
EDL89303.1
Gene_ORFName:
rCG_29249
Ensembl_TRS:
ENSRNOT00000028969
|
| Protein sequencees |
Ensembl_PRO:
ENSRNOP00000036927
RefSeq:
NP_036925.2
|
| Others |
UniRef100:
UniRef100_G3V960
UniRef90:
UniRef90_P10868
UniRef50:
UniRef50_P10868
UniGene:
Rn.33890
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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