| Type | Description |
|---|---|
| Definition | phenylalanine hydroxylase |
| Date | Results | Publications |
|---|---|---|
| 2018-05-05 10:20:00 | results support a model for allostery in PheH in which phenylalanine stabilizes the dimerization of the regulatory domains and exposes the active site for substrate binding and other structural changes needed for activity | 27145334 |
| 2016-08-20 10:09:00 | The results identify the location of the allosteric site as the interface of the regulatory domain dimer formed in activated PheH. | 26823465 |
| 2016-08-06 10:33:00 | use of SAXS and X-ray crystallography together to inspect PAH structure provides, to our knowledge, the first complete view of the enzyme in a tetrameric form that was not possible with prior partial crystal structures | 26884182 |
| 2015-11-07 10:27:00 | allosteric activation of phenylalanine hydroxylase is linked to dimerization of regulatory domains | 26252467 |
| 2015-02-21 11:12:00 | Data suggest that phenylalanine [concentration-dependent] activation of phenylalanine hydroxylase does not involve the active site; mutating the active-site residue Arg270 to lysine abolishes phenylalanine-dependent enzyme activation. | 25453233 |
| Type | IDs |
|---|---|
| Gene |
UniProtKB-ID:
Q6AYW2_RAT
UniprotKB:
Q6AYW2
UniParc:
UPI000019B809
EMBL:
BC078881,
CH473960,
AABR07056515,
AABR07056516,
AABR07056517
Ensembl:
ENSRNOG00000004302
KO:
rno:24616
|
| Nucleutide sequences |
EMBL-CDS:
EDM17035.1,
AAH78881.1
Gene_ORFName:
rCG_48893
Ensembl_TRS:
ENSRNOT00000005844
|
| Protein sequencees |
Ensembl_PRO:
ENSRNOP00000005844
RefSeq:
NP_036751.2,
XP_008763437.1
|
| Others |
UniRef100:
UniRef100_Q6AYW2
UniRef90:
UniRef90_P00439
UniRef50:
UniRef50_P00439
UniGene:
Rn.1652
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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