| Type | Description |
|---|---|
| Definition | heme binding protein 2 |
| Date | Results | Publications |
|---|---|---|
| 2017-09-23 10:33:00 | The gene copy numbers and mRNA levels for both ALG-2 and HEBP2 are significantly upregulated in breast and lung cancer. Coexpression of ALG-2 and HEBP2 markedly increases the cytoplasmic pool of ALG-2 and alters the subcellular distribution of HEBP2. Abnormalities in the ALG-2/HEBP2 interaction impairs spindle orientation and positioning during mitosis. | 28004381 |
| 2011-10-08 11:25:00 | There are important structural differences in the BH3 domain in the intact SOUL molecule and the same sequence bound to Bcl-xL. | 21639858 |
| 2010-02-15 12:10:00 | SOUL can be a novel member of the BH3 domain-only proteins that cannot induce cell death alone but can facilitate both outer and inner mitochondrial membrane permeabilization and predominantly necrotic cell death in oxidative stress. | 19901022 |
| 2010-01-21 00:00:00 | preliminary X ray structure | 19574650 |
| 2010-01-21 00:00:00 | SOUL promotes necrotic cell death by inducing mitochondrial permeability transition | 17098234 |
| Type | IDs |
|---|---|
| Synonymous | C6ORF34B, C6orf34, PP23, SOUL |
| Gene |
UniProtKB-ID:
HEBP2_HUMAN,
Q5THN1_HUMAN
UniprotKB:
Q9Y5Z4,
Q5THN1
UniParc:
UPI0000038D5D,
UPI000020E2EF,
UPI000007045D
EMBL:
AL391669,
AY427823,
AF117616,
BC008205,
BC093037,
AF411610,
BC010290,
AL031003
Ensembl:
ENSG00000051620
KO:
hsa:23593
|
| Nucleutide sequences |
EMBL-CDS:
AAH08205.1,
AAH93037.1,
AAR88624.1,
AAH10290.1,
AAL07394.1,
AAD32099.1
Ensembl_TRS:
ENST00000607197,
ENST00000367697
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000475750,
ENSP00000356670
RefSeq:
NP_001313309.1,
NP_001313310.1,
NP_055135.1
|
| Others |
UniRef100:
UniRef100_Q5THN1,
UniRef100_Q9Y5Z4
UniRef90:
UniRef90_Q9Y5Z4,
UniRef90_Q5THN1
UniRef50:
UniRef50_Q9Y5Z4,
UniRef50_Q5THN1
UniGene:
Hs.486589
CCDS:
CCDS5191.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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