| Type | Description |
|---|---|
| Definition | purine-nucleoside phosphorylase |
| Date | Results | Publications |
|---|---|---|
| 2019-01-19 12:14:00 | Loss of PNP expression is associated with hearing loss. | 30024931 |
| 2013-04-06 10:50:00 | PNP deficiency causes cerebellar abnormalities, including Purkinje cell damage and progressive motor deficits. | 22521465 |
| 2011-11-19 10:59:00 | PNP is important for the survival of DP thymocytes. Accumulation of dGuo in cases of PNP deficiency leads to mitochondria-initiated apoptosis of DP thymocytes, which can be prevented by restoring PNP activity in the cells. | 21868080 |
| Type | IDs |
|---|---|
| Synonymous | AL024301, AU015798, Np, Np-1, Np-2, Pnp1 |
| Gene |
UniProtKB-ID:
PNPH_MOUSE,
Q543K9_MOUSE
UniprotKB:
P23492,
Q543K9
UniParc:
UPI0000001856,
UPI00000040A4
EMBL:
X56548,
CT010254,
AK049817,
U35374,
AC136376,
L11292,
M84563,
BC052679,
BC003788,
L11291,
L11290,
CT010316,
AK153451
Ensembl:
ENSMUSG00000115338
KO:
mmu:18950
|
| Nucleutide sequences |
EMBL-CDS:
AAC37635.1,
AAA39835.1,
AAC37706.1,
CAA39888.1,
AAB60510.1,
AAH03788.1,
AAH52679.1,
CAJ18524.1,
AAC37634.1,
BAC33932.1,
BAE32005.1,
CAJ18462.1
Ensembl_TRS:
ENSMUST00000048615,
ENSMUST00000178092
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000136557,
ENSMUSP00000043926
RefSeq:
NP_038660.1
|
| Others |
UniRef100:
UniRef100_Q543K9,
UniRef100_P23492
UniRef90:
UniRef90_P23492
UniRef50:
UniRef50_P23492
UniGene:
Mm.17932
CCDS:
CCDS27029.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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