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18707 Pik3cd

18707

Pik3cd

phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta

protein-coding

Mus musculus

基因描述

Type Description
Definition phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta

研究结论

Date Results Publications
2020-09-12 16:04:00 Activated PI3Kdelta breaches multiple B cell tolerance checkpoints and causes autoantibody production. 31841125
2020-07-04 10:40:00 We conclude that inhibiting PI3Kdelta represents a novel therapeutic approach to ameliorate Alzheimer's disease pathology by dampening plaque accumulation and microglial-dependent neuroinflammation 31363064
2020-06-27 10:18:00 PI3KCD overactivation caused substantial increases in numbers of memory and follicular helper T (TFH) cells and dramatic changes in cytokine production in both patients and mice. 30738173
2020-06-20 11:23:00 PI3Kdelta-signaling mediates regulatory B cell immune differentiation when stimulated with resident microbiota or their components, and is critical for induction and regulatory function of IL-10-producing B cells in intestinal homeostasis and inflammation. 31546615
2020-04-11 10:13:00 3R)-5,6,7-trihydroxy-3-isopropyl-3-methylisochroman-1-one enhanced the therapeutic efficacy of anti-PD1 antibody through inhibiting PI3Kdelta/gamma. 31691624

名称对应

Type IDs
Synonymous 2410099E07Rik, 2610208K16Rik, AW545373, p110delta
Gene
UniProtKB-ID: PK3CD_MOUSE, Q3T9Y0_MOUSE, Q8CI98_MOUSE, Q8BS14_MOUSE, Q3TBW3_MOUSE, Q3UDT3_MOUSE
UniprotKB: O35904, Q3T9Y0, Q8CI98, Q8BS14, Q3TBW3, Q3UDT3
UniParc: UPI00000E8BC2, UPI00001D686E, UPI000287A2DC, UPI00000EAD57, UPI00005B2759, UPI0000356973, UPI000056681C
EMBL: AK040867, AL607078, CU207384, AF532989, AL626808, AK171025, CH466594, AK172222, BC035203, AK149935, U86587, CT010349
Ensembl: ENSMUSG00000039936
KO: mmu:18707
Nucleutide sequences
EMBL-CDS: AAC25676.1, AAN05615.1, EDL14872.1, BAE42890.1, CAJ18557.1, AAH35203.2, BAC30725.1, BAE42194.1, BAE29178.1
Ensembl_TRS: ENSMUST00000105689, ENSMUST00000105690, ENSMUST00000177654, ENSMUST00000038859, ENSMUST00000118704, ENSMUST00000105688
Protein sequencees
Ensembl_PRO: ENSMUSP00000101314, ENSMUSP00000101315, ENSMUSP00000136045, ENSMUSP00000036434, ENSMUSP00000112863, ENSMUSP00000101313
RefSeq: XP_030109175.1, XP_006538704.1, XP_030109174.1, XP_006538705.1, NP_001157524.1, XP_036019723.1, XP_006538711.1, XP_017175526.1, XP_006538712.1, XP_036019724.1, XP_006538710.1, XP_006538707.1, XP_036019725.1, XP_006538715.1, XP_036019722.1, XP_006538713.1, XP_006538706.1, XP_006538714.1, XP_006538709.1, NP_001157521.1, NP_001025008.2, XP_030109173.1, XP_017175527.1, NP_001157523.1, NP_032866.2, XP_006538716.1, NP_001157522.1, XP_006538708.1
Others
UniRef100: UniRef100_O35904, UniRef100_Q3T9Y0, UniRef100_Q3UDT3, UniRef100_Q8BS14, UniRef100_Q8CI98, UniRef100_Q3TBW3
UniRef90: UniRef90_Q3TBW3, UniRef90_H0VMM3, UniRef90_Q3T9Y0, UniRef90_O00329
UniRef50: UniRef50_O00329
UniGene: Mm.229108
CCDS: CCDS51380.1

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