| Type | Description |
|---|---|
| Definition | procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha 1 polypeptide |
| Date | Results | Publications |
|---|---|---|
| 2021-02-13 13:22:00 | Superoxide-induced Type I collagen secretion depends on prolyl 4-hydroxylases. | 32819558 |
| 2019-12-14 10:56:00 | miR-124-3p inhibits vascular smooth muscle cell collagen synthesis by directly targeting P4HA1, which might decrease atherosclerotic plaque stability. | 30193190 |
| 2019-10-19 10:25:00 | AMPKalpha/AP-2alpha/miR-124/P4Halpha1 axis plays a crucial role in the regulation of collagen synthesis in advanced atherosclerotic lesions. Targeting AMPKalpha/AP-2alpha/miRNA-124/P4Halpha1 signaling should be considered to increase the plaque stability in patients with atherosclerosis. | 29502204 |
| 2019-08-31 10:16:00 | N259 glycosylation induces P4HA1 to hydroxylate specific prolines in collagen 1 alpha 2, resulting in more pepsin-resistant collagen. Silencing STT3B or magnesium transporter 1 (MAGT1), the enzymes responsible for N259 glycosylation on P4HA1, significantly decreases hydroxylation of five prolines in collagen 1 alpha 2 and eight prolines in collagen 1alpha 1. | 30919021 |
| 2017-02-25 11:22:00 | Overexpression of P4Ha1 increased atherosclerotic plaque size. | 27818566 |
| Type | IDs |
|---|---|
| Synonymous | AL022634, P4ha |
| Gene |
UniProtKB-ID:
P4HA1_MOUSE,
E9Q7B0_MOUSE,
Q3UF16_MOUSE,
Q3TTT2_MOUSE
UniprotKB:
Q60715,
E9Q7B0,
Q3UF16,
Q3TTT2
UniParc:
UPI0000004068,
UPI0000028431,
UPI00005AC84E,
UPI0000D8AFDC,
UPI00005B1D03
EMBL:
BC009654,
AK160798,
AK169726,
AC157089,
AK149127,
AK045008,
AK161212,
U16162
Ensembl:
ENSMUSG00000019916
KO:
mmu:18451
|
| Nucleutide sequences |
EMBL-CDS:
BAE41331.1,
AAH09654.1,
BAE36020.1,
BAC32183.1,
AAC52197.1,
BAE28745.1,
BAE36242.1
Ensembl_TRS:
ENSMUST00000105466,
ENSMUST00000009789,
ENSMUST00000092512
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000101106,
ENSMUSP00000009789,
ENSMUSP00000090170
RefSeq:
NP_001303299.1,
NP_035160.1,
NP_001303300.1
|
| Others |
UniRef100:
UniRef100_E9Q7B0,
UniRef100_Q3TTT2,
UniRef100_Q60715,
UniRef100_Q3UF16
UniRef90:
UniRef90_P13674,
UniRef90_Q3UF16
UniRef50:
UniRef50_P13674
UniGene:
Mm.2212
CCDS:
CCDS83698.1,
CCDS23863.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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