| Type | Description |
|---|---|
| Definition | orthopedia homeobox |
| Date | Results | Publications |
|---|---|---|
| 2019-01-19 11:50:00 | We tested the functional consequences of the novel human OTP mutations and Q83K as well as the mouse R108W mutant; all affect residues that are highly conserved across species. On a single site response element, wild-type OTP was found to act as a repressor; both R108W and Q153R abolished this repression | 29107289 |
| 2018-12-22 10:28:00 | Studies revealed that Dlx1/2 and Otp are required for the specification of growth hormone-releasing hormone (GHRH)- and AgRP-neurons, respectively. Dlx1/2 suppress agouti-related protein (AgRP)-neuronal fate by directly binding and repressing the Otp gene, uncovering a novel Dlx1/2-Otp gene regulatory axis critical for the segregation of GHRH- and AgRP-neuronal fates. | 29795232 |
| 2013-06-15 12:06:00 | Otp and TTF-1 are essential for the normal morphological development of the hypothalamus, including the arcuate nucleus [review] | 23276958 |
| 2010-06-28 11:58:00 | diencephalic neurons colonize the telencephalic amygdaloid complex, migrating along a tangential route that crosses a boundary between developing brain vesicles. The diencephalic transcription factor OTP was necessary for this migratory behavior | 20495559 |
| Type | IDs |
|---|---|
| Gene |
UniProtKB-ID:
OTP_MOUSE
UniprotKB:
O09113
UniParc:
UPI0000021CAA
EMBL:
Y10413
Ensembl:
ENSMUSG00000021685
KO:
mmu:18420
|
| Nucleutide sequences |
EMBL-CDS:
CAA71439.1
Ensembl_TRS:
ENSMUST00000022195
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000022195
RefSeq:
XP_006517630.1,
XP_006517631.1,
NP_035151.1
|
| Others |
UniRef100:
UniRef100_Q5XKR4
UniRef90:
UniRef90_Q5XKR4
UniRef50:
UniRef50_Q5XKR4
UniGene:
Mm.42051
CCDS:
CCDS26695.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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Ensembl: {{protein.nucleotideEnsembl}} |
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Definition: {{{protein.definition}}}Transcript Veriant:{{protein.transcriptVeriant}} Status: {{protein.status}} |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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