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18022 Nfe2

18022

Nfe2

nuclear factor, erythroid derived 2

protein-coding

Mus musculus

基因描述

Type Description
Definition nuclear factor, erythroid derived 2

研究结论

Date Results Publications
2019-12-28 10:51:00 mutations in NFE2 predispose to the acquisition of secondary changes promoting the development of myelosarcoma and/or AML 30755419
2019-09-14 10:20:00 We detected that cigarette smoke significantly increased p45 NFE2 levels in DJ-1 KO mice compared to wild-type mice. Our results indicate that p45 NFE2 expression is induced by exposure to cigarette smoke, has a cytoprotective activity against cell injury, and its downregulation in human primary ATII cells may contribute to emphysema pathogenesis 29476075
2018-04-21 10:47:00 Histones showed limited activation in regions of single TF binding, while enhancers that bind NF-E2 and either RUNX1, FLI1 or both TFs gave the highest signals for TF occupancy and H3K4me2; these enhancers associated best with genes activated late in MK maturation. 27457419
2017-09-02 13:46:00 Under the obese condition, activation of the hepatic NFE2/miR-423-5p axis plays important roles in the progression of type 2 diabetes and NAFLD by repressing the FAM3A-ATP-Akt signaling pathway. 28411267
2017-07-15 10:37:00 results suggest that Nrf2 deficiency induced by HFD promoted hepatic fatty acid metabolism disorder by altering 18-carbon and 22-carbon fatty acid composition 27311796

名称对应

Type IDs
Synonymous NF-E2, NF-E2/P45, p45, p45NFE2, p45nf-e2
Gene
UniProtKB-ID: NFE2_MOUSE, A0A0R4J0Y5_MOUSE, D3Z224_MOUSE
UniprotKB: Q07279, A0A0R4J0Y5, D3Z224
UniParc: UPI0000023D7C, UPI00000279FA, UPI000198D057
EMBL: BC062171, L09600, AK156702, AC164069
Ensembl: ENSMUSG00000058794
KO: mmu:18022
Nucleutide sequences
EMBL-CDS: AAH62171.1, BAE33812.1, AAA40417.1
Ensembl_TRS: ENSMUST00000156927, ENSMUST00000134554, ENSMUST00000075192, ENSMUST00000149111, ENSMUST00000133600
Protein sequencees
Ensembl_PRO: ENSMUSP00000114160, ENSMUSP00000074684, ENSMUSP00000117474, ENSMUSP00000122476, ENSMUSP00000121817
RefSeq: NP_001289270.1, XP_030104235.1, NP_001289272.1, NP_001289267.1, NP_001289269.1, NP_032711.2, XP_036015117.1, XP_006520636.1, NP_001289268.1
Others
UniRef100: UniRef100_Q07279, UniRef100_A0A0R4J0Y5, UniRef100_D3Z224
UniRef90: UniRef90_Q07279, UniRef90_A0A0R4J0Y5
UniRef50: UniRef50_G1L1M5, UniRef50_Q16621
UniGene: Mm.457989
CCDS: CCDS27900.1

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