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179592 sas-5

179592

sas-5

Spindle assembly abnormal protein 5

protein-coding

Caenorhabditis elegans

基因描述

Type Description
Definition Spindle assembly abnormal protein 5

研究结论

Date Results Publications
2019-02-09 12:43:00 The interdependence of SAS-5 oligomerization and microtubule binding reflects an avidity mechanism, which also strengthens SAS-5 associations with other centriole components and, thus, promotes organelle assembly. 29367435
2018-07-21 11:54:00 Our data suggest that the APC/C(FZR-1) regulates SAS-5 levels by directly recognizing the conserved KEN-box motif, contributing to proper centrosome duplication. Together, our work shows that FZR-1 plays a conserved role in regulating centrosome duplication in C. elegans 29030390
2016-03-12 10:18:00 Disruption of either domain leads to centriole duplication failure in worm embryos, indicating that large SAS-5 assemblies are necessary for function in vivo. 26023830
2013-02-09 10:58:00 It was demonstrated that the short SAS-5 C-terminal domain (residues 390-404) specifically binds to a narrow central region (residues 275-288) of the SAS-6 coiled coil. 23064147
2010-01-21 00:00:00 SAS-5 has a role in nuclear morphology in Caenorhabditis elegans 15724817

名称对应

Type IDs
Gene
UniProtKB-ID: SAS5_CAEEL
UniprotKB: Q20010
UniParc: UPI00001793E8, UPI0000082528
EMBL: Z74032
EnsemblGenome: WBGene00009385
KO: cel:CELE_F35B12.5
Nucleutide sequences
EMBL-CDS: CCD31072.1, CAA98463.2
Gene_ORFName: F35B12.5
EnsemblGenome_TRS: F35B12.5c.2, F35B12.5a.1, F35B12.5a.2, F35B12.5c.1
Protein sequencees
EnsemblGenome_PRO: F35B12.5c.2, F35B12.5c.1, F35B12.5a.2, F35B12.5a.1
RefSeq: NP_001256338.1, NP_001256339.1
Others
UniRef100: UniRef100_Q20010
UniRef90: UniRef90_Q20010
UniRef50: UniRef50_Q20010
UniGene: Cel.3763

全选

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研究热度

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