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176868 eri-1

176868

eri-1

3'-5' exonuclease eri-1

protein-coding

Caenorhabditis elegans

基因描述

Type Description
Definition 3'-5' exonuclease eri-1

研究结论

Date Results Publications
2017-03-18 11:04:00 In the absence of eri-1, reserpine mediated lifespan extension (RMLE) is shortened. In the dop-3 loss-of-function background, lack of eri-1 completely abolishes RMLE. This suggests that dop-3 and eri-1 act in independent parallel pathways for RMLE and these two pathways are essential and sufficient for the longevity enhancement by reserpine in C. elegans. 27966489
2010-02-22 11:32:00 results identify novel components of the endo machinery, demonstrate differential requirements for the Eri factors in the sperm-producing germline, and begin to delineate the functional requirement for the ERI/DICER complex in sperm development 19797044
2010-01-21 00:00:00 In C. elegans, two protein isoforms of ERI-1 are localized to the cytoplasm, and each has distinct functions in ribosomal RNA processing and negative regulation of RNA interference. 18438419
2010-01-21 00:00:00 After exposure to dsRNA or siRNAs, animals with eri-1 mutations accumulate more siRNAs than wild-type animals; a negative regulator that may normally function to limit the duration, cell-type specificity or endogenous functions of RNA interference 14961122
2010-01-21 00:00:00 These results provide additional support for the hypothesis that RRF-3 and ERI-1 act together in the endo-siRNA pathway, and furthermore suggests their involvement in additional biological processes. 17919598

名称对应

Type IDs
Gene
UniProtKB-ID: ERI1_CAEEL
UniprotKB: O44406
UniParc: UPI000007D425, UPI00000786A0
EMBL: FO081716
EnsemblGenome: WBGene00001332
KO: cel:CELE_T07A9.5
Nucleutide sequences
EMBL-CDS: CCD73975.1, CCD73976.1
Gene_ORFName: T07A9.5
EnsemblGenome_TRS: T07A9.5a.1, T07A9.5b.1
Protein sequencees
EnsemblGenome_PRO: T07A9.5a.1, T07A9.5b.1
RefSeq: NP_741292.1, NP_741293.1, NP_001368343.1, NP_001368344.1
Others
UniRef100: UniRef100_O44406
UniRef90: UniRef90_O44406
UniRef50: UniRef50_O44406
UniGene: Cel.12380

全选

研究热度
该基因近6年没有文献发表
热点单位
排名 科研单位 文献
1

McGill University

2
2

University of Wisconsin

2
3

Ursinus College

2
4

Department of Molecular Biology, Massachusetts General Hospital and Department of Genetics, Harvard Medical School, Boston, Massachusetts 02114, USA.

1
5

University of Massachusetts Medical School

1
热点人员
排名 研究人员 文献
1

Thomas F Duchaine

4
2

Scott Kennedy

3
3

Gary Ruvkun

3
4

Darryl Conte

2
5

Craig C Mello

2
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