Type | Description |
---|---|
Definition | 3'-5' exonuclease eri-1 |
Date | Results | Publications |
---|---|---|
2017-03-18 11:04:00 | In the absence of eri-1, reserpine mediated lifespan extension (RMLE) is shortened. In the dop-3 loss-of-function background, lack of eri-1 completely abolishes RMLE. This suggests that dop-3 and eri-1 act in independent parallel pathways for RMLE and these two pathways are essential and sufficient for the longevity enhancement by reserpine in C. elegans. | 27966489 |
2010-02-22 11:32:00 | results identify novel components of the endo machinery, demonstrate differential requirements for the Eri factors in the sperm-producing germline, and begin to delineate the functional requirement for the ERI/DICER complex in sperm development | 19797044 |
2010-01-21 00:00:00 | In C. elegans, two protein isoforms of ERI-1 are localized to the cytoplasm, and each has distinct functions in ribosomal RNA processing and negative regulation of RNA interference. | 18438419 |
2010-01-21 00:00:00 | After exposure to dsRNA or siRNAs, animals with eri-1 mutations accumulate more siRNAs than wild-type animals; a negative regulator that may normally function to limit the duration, cell-type specificity or endogenous functions of RNA interference | 14961122 |
2010-01-21 00:00:00 | These results provide additional support for the hypothesis that RRF-3 and ERI-1 act together in the endo-siRNA pathway, and furthermore suggests their involvement in additional biological processes. | 17919598 |
Type | IDs |
---|---|
Gene |
UniProtKB-ID:
ERI1_CAEEL
UniprotKB:
O44406
UniParc:
UPI000007D425,
UPI00000786A0
EMBL:
FO081716
EnsemblGenome:
WBGene00001332
KO:
cel:CELE_T07A9.5
|
Nucleutide sequences |
EMBL-CDS:
CCD73975.1,
CCD73976.1
Gene_ORFName:
T07A9.5
EnsemblGenome_TRS:
T07A9.5a.1,
T07A9.5b.1
|
Protein sequencees |
EnsemblGenome_PRO:
T07A9.5a.1,
T07A9.5b.1
RefSeq:
NP_741292.1,
NP_741293.1,
NP_001368343.1,
NP_001368344.1
|
Others |
UniRef100:
UniRef100_O44406
UniRef90:
UniRef90_O44406
UniRef50:
UniRef50_O44406
UniGene:
Cel.12380
|
排名 | 科研单位 | 文献 |
---|---|---|
1 |
McGill University |
2 |
2 |
University of Wisconsin |
2 |
3 |
Ursinus College |
2 |
4 |
Department of Molecular Biology, Massachusetts General Hospital and Department of Genetics, Harvard Medical School, Boston, Massachusetts 02114, USA. |
1 |
5 |
University of Massachusetts Medical School |
1 |
排名 | 研究人员 | 文献 |
---|---|---|
1 |
Thomas F Duchaine |
4 |
2 |
Scott Kennedy |
3 |
3 |
Gary Ruvkun |
3 |
4 |
Darryl Conte |
2 |
5 |
Craig C Mello |
2 |