The exonuclease ERI-1 has a conserved dual role in 5.8S rRNA processing and RNAi.
Nat Struct Mol Biol. 2008 May;15(5):531-3. Epub 2008 Apr 27
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摘要
The exonuclease ERI-1 negatively regulates RNA interference in Caenorhabditis elegans and Schizosaccharomyces pombe, and is required for production of some C. elegans endogenous small interfering RNAs. We show that ERI-1 performs 3' end processing of the 5.8S ribosomal RNA in both C. elegans and S. pombe. In C. elegans, two protein isoforms of ERI-1 are localized to the cytoplasm, and each has distinct functions in ribosomal RNA processing and negative regulation of RNA interference.
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基因功能
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原始数据
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文献解读
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