| Type | Description |
|---|---|
| Definition | monoamine oxidase A |
| Date | Results | Publications |
|---|---|---|
| 2020-05-16 12:40:00 | MAOA expression and enzyme activity was reduced in hypothalamus and increased in prefrontal cortex of prepubertally stressed hyper-aggressive male mice. Hypomethylation in prefrontal cortex and hypermethylation in hypothalamus of MAOA promoter negatively correlated with the expression pattern. Sirt1 binding to the MAOA promoter was increased in prefrontal cortex and reduced in hypothalamus. In females, MAO was unchanged. | 31348967 |
| 2019-09-14 12:52:00 | MAO inhibition prevented both mast cell degranulation and altered collagen deposition, thereby normalizing diastolic function. These results elucidate the mechanisms underlying MAO-induced damage in diabetic cardiomyopathy and provide novel evidence for the role of MAOs in inflammation and inter-organelle communication. | 29459772 |
| 2019-09-14 10:32:00 | Reactive oxygen species produced by MAO-A lead to the accumulation of p53 in the cytosol where it inhibits parkin, an important regulator of mitophagy, resulting in mitochondrial dysfunction. | 30003648 |
| 2019-08-17 10:14:00 | mice lacking both MAO isoforms, MAOA and MAOB, exhibit smaller prostate mass and develop epithelial atrophy in the ventral and dorsolateral prostates. | 29637670 |
| 2019-02-23 12:28:00 | Loss of MAOA in epithelia inhibits adenocarcinoma development, cell proliferation and cancer stem cells in prostate | 29844571 |
| Type | IDs |
|---|---|
| Synonymous | 1110061B18Rik, AA407771 |
| Gene |
UniProtKB-ID:
AOFA_MOUSE,
Q3UJ53_MOUSE,
Q3TPD9_MOUSE
UniprotKB:
Q64133,
Q3UJ53,
Q3TPD9
UniParc:
UPI00005AC58B,
UPI0000192E09,
UPI00005B2085
EMBL:
S78615,
BC029100,
AL805907,
S78606,
AK146612,
AL831729,
AK164457,
CH466584
Ensembl:
ENSMUSG00000025037
KO:
mmu:17161
|
| Nucleutide sequences |
EMBL-CDS:
AAH29100.1,
EDL35717.1,
AAB34677.1,
BAE27302.1,
BAE37797.1
Ensembl_TRS:
ENSMUST00000026013
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000026013
RefSeq:
NP_776101.3
|
| Others |
UniRef100:
UniRef100_Q3UJ53,
UniRef100_Q64133
UniRef90:
UniRef90_P21396
UniRef50:
UniRef50_P21396
UniGene:
Mm.21108
CCDS:
CCDS30033.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
{{protein.nucleotideVersion}}
Ensembl: {{protein.nucleotideEnsembl}} |
{{protein.proteinVersion}}
Ensembl: {{protein.proteinEnsembl}} |
{{uniprot}} , |
Definition: {{{protein.definition}}}Transcript Veriant:{{protein.transcriptVeriant}} Status: {{protein.status}} |
||||
| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
||||
暂无数据
| 排名 | 科研单位 | 文献 |
|---|---|---|
| {{affIndex+1}} |
{{aff.value}} |
{{aff.size}} |
目前还没有研究热点单位
| 排名 | 研究人员 | 文献 |
|---|---|---|
| {{authorIndex+1}} |
{{author.value}} |
{{author.size}} |
目前还没有研究热点人员