| Type | Description |
|---|---|
| Definition | BCDIN3 domain containing RNA methyltransferase |
| Date | Results | Publications |
|---|---|---|
| 2020-03-21 10:36:00 | CDIN3D is a tRNAHis-specific 5'-monomethylphosphate capping enzyme that discriminates tRNAHis from other tRNA species, and the structural information presented in this study also provides the molecular basis for the development of drugs against breast cancers. | 31919512 |
| 2019-12-21 12:02:00 | Results indicate that tRNAHis interaction with BCDIN3D plays non-canonical roles, one of which is to regulate the generation of tRNAHis 3' fragments. | 31329584 |
| 2018-02-03 11:42:00 | BCDIN3D might serve as an important prognostic factor for triple-negative breast cancer | 27259993 |
| 2017-09-23 10:22:00 | BCDIN3D acts as a cytoplasmic tRNAHis-specific 5-methylphosphate capping enzyme. | 28119416 |
| 2017-02-17 08:06:00 | Human BCDIN3D monomethylates the 5'-monophosphate of cytoplasmic tRNAHis in vitro. In BCDN3D-knockout cells, established byCRISPR/Cas9 editing, the methyl moiety at the 5'-monophosphate of cytoplasmic tRNAHis is lost, and the exogenous expression of BCDIN3D in the knockout cells restores the modification in cytoplasmic tRNAHis. | 28119416 |
| Type | IDs |
|---|---|
| Gene |
UniProtKB-ID:
BN3D2_HUMAN
UniprotKB:
Q7Z5W3
UniParc:
UPI0000160802
EMBL:
BC053560,
AK292194,
CH471111
Ensembl:
ENSG00000186666
KO:
hsa:144233
|
| Nucleutide sequences |
EMBL-CDS:
EAW58101.1,
BAF84883.1,
AAH53560.1
Ensembl_TRS:
ENST00000333924
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000335201
RefSeq:
NP_859059.1
|
| Others |
UniRef100:
UniRef100_Q7Z5W3
UniRef90:
UniRef90_Q7Z5W3
UniRef50:
UniRef50_Q7Z5W3
UniGene:
Hs.142736
CCDS:
CCDS8790.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
{{protein.nucleotideVersion}}
Ensembl: {{protein.nucleotideEnsembl}} |
{{protein.proteinVersion}}
Ensembl: {{protein.proteinEnsembl}} |
{{uniprot}} , |
Definition: {{{protein.definition}}}Transcript Veriant:{{protein.transcriptVeriant}} Status: {{protein.status}} |
||||
| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
||||
暂无数据
| Pubmed编号 | 文献信息 | 发表日期 | 相关基因 |
|---|---|---|---|
| 31919512 |
Crystal structure of human cytoplasmic tRNAHis-specific 5'-monomethylphosphate capping enzyme. Nucleic Acids Res. Yining Liu , Anna Martinez , Seisuke Yamashita , Kozo Tomita |
2020-02-20 | - |
| 31329584 |
BCDIN3D regulates tRNAHis 3' fragment processing. PLoS Genet. Calder W Reinsborough , Hélène Ipas , Nathan S Abell , Ryan M Nottingham , Jun Yao , Sravan K Devanathan , Samantha B Shelton , Alan M Lambowitz , Blerta Xhemalçe |
2019-07-01 | - |
| 28514442 |
Architecture of the human interactome defines protein communities and disease networks. Nature Edward L Huttlin , Raphael J Bruckner , Joao A Paulo , Joe R Cannon , Lily Ting , Kurt Baltier , Greg Colby , Fana Gebreab , Melanie P Gygi , Hannah Parzen , John Szpyt , Stanley Tam , Gabriela Zarraga , Laura Pontano-Vaites , Sharan Swarup , Anne E White , Devin K Schweppe , Ramin Rad , Brian K Erickson , Robert A Obar , K G Guruharsha , Kejie Li , Spyros Artavanis-Tsakonas , Steven P Gygi , J Wade Harper |
2017-05-25 | - |
| 28119416 |
Human BCDIN3D monomethylates cytoplasmic histidine transfer RNA. Nucleic Acids Res. Anna Martinez , Seisuke Yamashita , Takashi Nagaike , Yuriko Sakaguchi , Tsutomu Suzuki , Kozo Tomita |
2017-05-19 | - |
| 27581605 |
A Suite of Biochemical Assays for Screening RNA Methyltransferase BCDIN3D. SLAS Discov Levi L Blazer , Fengling Li , Steven Kennedy , Yujun George Zheng , Cheryl H Arrowsmith , Masoud Vedadi |
2017-01-01 | - |
| 27259993 |
Elevated expression of RNA methyltransferase BCDIN3D predicts poor prognosis in breast cancer. Oncotarget Ling Yao , Yayun Chi , Xin Hu , Shan Li , Feng Qiao , Jong Wu , Zhi-Ming Shao |
2016-08-16 | - |
| 25416956 |
A proteome-scale map of the human interactome network. Cell Thomas Rolland , Murat TaÅan , Benoit Charloteaux , Samuel J Pevzner , Quan Zhong , Nidhi Sahni , Song Yi , Irma Lemmens , Celia Fontanillo , Roberto Mosca , Atanas Kamburov , Susan D Ghiassian , Xinping Yang , Lila Ghamsari , Dawit Balcha , Bridget E Begg , Pascal Braun , Marc Brehme , Martin P Broly , Anne-Ruxandra Carvunis , Dan Convery-Zupan , Roser Corominas , Jasmin Coulombe-Huntington , Elizabeth Dann , Matija Dreze , Amélie Dricot , Changyu Fan , Eric Franzosa , Fana Gebreab , Bryan J Gutierrez , Madeleine F Hardy , Mike Jin , Shuli Kang , Ruth Kiros , Guan Ning Lin , Katja Luck , Andrew MacWilliams , Jörg Menche , Ryan R Murray , Alexandre Palagi , Matthew M Poulin , Xavier Rambout , John Rasla , Patrick Reichert , Viviana Romero , Elien Ruyssinck , Julie M Sahalie , Annemarie Scholz , Akash A Shah , Amitabh Sharma , Yun Shen , Kerstin Spirohn , Stanley Tam , Alexander O Tejeda , Shelly A Trigg , Jean-Claude Twizere , Kerwin Vega , Jennifer Walsh , Michael E Cusick , Yu Xia , Albert-László Barabási , Lilia M Iakoucheva , Patrick Aloy , Javier De Las Rivas , Jan Tavernier , Michael A Calderwood , David E Hill , Tong Hao , Frederick P Roth , Marc Vidal |
2014-11-20 | - |
| 25231870 |
Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche. Nature John Rb Perry , Felix Day , Cathy E Elks , Patrick Sulem , Deborah J Thompson , Teresa Ferreira , Chunyan He , Daniel I Chasman , Tõnu Esko , Gudmar Thorleifsson , Eva Albrecht , Wei Q Ang , Tanguy Corre , Diana L Cousminer , Bjarke Feenstra , Nora Franceschini , Andrea Ganna , Andrew D Johnson , Sanela Kjellqvist , Kathryn L Lunetta , George McMahon , Ilja M Nolte , Lavinia Paternoster , Eleonora Porcu , Albert V Smith , Lisette Stolk , Alexander Teumer , Natalia TÅ¡ernikova , Emmi Tikkanen , Sheila Ulivi , Erin K Wagner , Najaf Amin , Laura J Bierut , Enda M Byrne , Jouke-Jan Hottenga , Daniel L Koller , Massimo Mangino , Tune H Pers , Laura M Yerges-Armstrong , Jing Hua Zhao , Irene L Andrulis , Hoda Anton-Culver , Femke Atsma , Stefania Bandinelli , Matthias W Beckmann , Javier Benitez , Carl Blomqvist , Stig E Bojesen , Manjeet K Bolla , Bernardo Bonanni , Hiltrud Brauch , Hermann Brenner , Julie E Buring , Jenny Chang-Claude , Stephen Chanock , Jinhui Chen , Georgia Chenevix-Trench , J Margriet Collée , Fergus J Couch , David Couper , Andrea D Coveillo , Angela Cox , Kamila Czene , Adamo Pio D'adamo , George Davey Smith , Immaculata De Vivo , Ellen W Demerath , Joe Dennis , Peter Devilee , Aida K Dieffenbach , Alison M Dunning , Gudny Eiriksdottir , Johan G Eriksson , Peter A Fasching , Luigi Ferrucci , Dieter Flesch-Janys , Henrik Flyger , Tatiana Foroud , Lude Franke , Melissa E Garcia , Montserrat GarcÃa-Closas , Frank Geller , Eco Ej de Geus , Graham G Giles , Daniel F Gudbjartsson , Vilmundur Gudnason , Pascal Guénel , Suiqun Guo , Per Hall , Ute Hamann , Robin Haring , Catharina A Hartman , Andrew C Heath , Albert Hofman , Maartje J Hooning , John L Hopper , Frank B Hu , David J Hunter , David Karasik , Douglas P Kiel , Julia A Knight , Veli-Matti Kosma , Zoltan Kutalik , Sandra Lai , Diether Lambrechts , Annika Lindblom , Reedik Mägi , Patrik K Magnusson , Arto Mannermaa , Nicholas G Martin , Gisli Masson , Patrick F McArdle , Wendy L McArdle , Mads Melbye , Kyriaki Michailidou , Evelin Mihailov , Lili Milani , Roger L Milne , Heli Nevanlinna , Patrick Neven , Ellen A Nohr , Albertine J Oldehinkel , Ben A Oostra , Aarno Palotie , Munro Peacock , Nancy L Pedersen , Paolo Peterlongo , Julian Peto , Paul Dp Pharoah , Dirkje S Postma , Anneli Pouta , Katri Pylkäs , Paolo Radice , Susan Ring , Fernando Rivadeneira , Antonietta Robino , Lynda M Rose , Anja Rudolph , Veikko Salomaa , Serena Sanna , David Schlessinger , Marjanka K Schmidt , Mellissa C Southey , Ulla Sovio , Meir J Stampfer , Doris Stöckl , Anna M Storniolo , Nicholas J Timpson , Jonathan Tyrer , Jenny A Visser , Peter Vollenweider , Henry Völzke , Gerard Waeber , Melanie Waldenberger , Henri Wallaschofski , Qin Wang , Gonneke Willemsen , Robert Winqvist , Bruce Hr Wolffenbuttel , Margaret J Wright , Australian Ovarian Cancer Study , GENICA Network , kConFab , LifeLines Cohort Study , InterAct Consortium , Early Growth Genetics (EGG) Consortium , Dorret I Boomsma , Michael J Econs , Kay-Tee Khaw , Ruth Jf Loos , Mark I McCarthy , Grant W Montgomery , John P Rice , Elizabeth A Streeten , Unnur Thorsteinsdottir , Cornelia M van Duijn , Behrooz Z Alizadeh , Sven Bergmann , Eric Boerwinkle , Heather A Boyd , Laura Crisponi , Paolo Gasparini , Christian Gieger , Tamara B Harris , Erik Ingelsson , Marjo-Riitta Järvelin , Peter Kraft , Debbie Lawlor , Andres Metspalu , Craig E Pennell , Paul M Ridker , Harold Snieder , Thorkild Ia Sørensen , Tim D Spector , David P Strachan , André G Uitterlinden , Nicholas J Wareham , Elisabeth Widen , Marek Zygmunt , Anna Murray , Douglas F Easton , Kari Stefansson , Joanne M Murabito , Ken K Ong |
2014-10-02 | - |
| 25626080 |
RNA methyltransferases involved in 5' cap biosynthesis. RNA Biol Magdalena Byszewska , MirosÅaw ÅmietaÅski , Elżbieta Purta , Janusz M Bujnicki |
2014-01-01 | - |
| 23063121 |
Human RNA methyltransferase BCDIN3D regulates microRNA processing. Cell Blerta Xhemalce , Samuel C Robson , Tony Kouzarides |
2012-10-12 | - |
| 排名 | 科研单位 | 文献 |
|---|---|---|
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