| Type | Description |
|---|---|
| Definition | chloride channel, voltage-sensitive 3 |
| Date | Results | Publications |
|---|---|---|
| 2020-12-12 13:28:00 | Uncoupling endosomal CLC chloride/proton exchange causes severe neurodegeneration. | 32118314 |
| 2020-05-16 12:14:00 | ClC-3 plays a critical role in the angiogenic capacity of EPCs and EPC-mediated neovascularization of ischemic tissues. Disturbance of CXCR4/JAK-2 signalling may contribute to the functional impairment of ClC-3 deficient EPCs. Thus, ClC-3 may be a potential therapeutic target for modulating neovascularization in ischemic diseases. | 31679624 |
| 2018-09-22 10:49:00 | intracellular Cl(-) regulation by ANO1/ClC-3 participates in HER2 transcription, mediating the PI3K/AKT/mTOR and/or signaling pathway(s) in HER2-positive breast cancer cells. | 29949674 |
| 2018-04-21 10:16:00 | Abrogating ClC-3 blunts lipopolysaccharide-induced Inflammation via blocking the TLR4/NF-kappaB pathway. | 27363391 |
| 2017-12-30 12:01:00 | Results have shown that the expression of ClC-3 was reduced in hypertrophic H9c2 cells, primary rat neonatal cardiomyocytes and myocardium of C57/BL/6 mice and that ClC-3 played an important role in beta-adrenergic cardiac hypertrophy. | 29158167 |
| Type | IDs |
|---|---|
| Synonymous | Clc3 |
| Gene |
UniProtKB-ID:
CLCN3_MOUSE,
E9Q2I1_MOUSE,
Q8K4W8_MOUSE,
Q790S0_MOUSE
UniprotKB:
P51791,
E9Q2I1,
Q8K4W8,
Q790S0
UniParc:
UPI00001F5E9C,
UPI000000130C,
UPI0003D711CA,
UPI00157F7F32,
UPI00157F7F3F,
UPI00000E7DE1,
UPI00157F7F3D,
UPI0000564898
EMBL:
AK169297,
AK162639,
AF347683,
AH011751,
X78874,
CH466569,
AF347687,
AF347682,
AF347684,
AF347685,
AC114920,
AF029347,
AF347686,
AK159698,
AF347689,
AK141136,
AF347688,
AK150688
Ensembl:
ENSMUSG00000004319
KO:
mmu:12725
|
| Nucleutide sequences |
EMBL-CDS:
BAE37002.1,
BAE24568.1,
AAB95162.1,
BAE35298.1,
BAE29767.1,
AAM89117.1,
EDL28642.1,
AAM89113.1,
BAE41053.1,
CAA55476.1,
AAM89115.1,
AAM89114.1
Ensembl_TRS:
ENSMUST00000004430,
ENSMUST00000110302,
ENSMUST00000056508,
ENSMUST00000093490
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000004430,
ENSMUSP00000105931,
ENSMUSP00000058648,
ENSMUSP00000091202
RefSeq:
XP_036009634.1,
XP_017168041.1,
NP_776299.1,
NP_776298.1,
XP_036009633.1,
NP_776301.1,
NP_031737.1,
XP_006509323.1,
XP_006509322.1,
XP_017168042.1
|
| Others |
UniRef100:
UniRef100_Q790S0,
UniRef100_P51791,
UniRef100_Q8K4W8,
UniRef100_E9Q2I1
UniRef90:
UniRef90_Q790S0,
UniRef90_P51791,
UniRef90_P51791-4
UniRef50:
UniRef50_P51791
UniGene:
Mm.25263,
Mm.259751
CCDS:
CCDS22323.1,
CCDS52554.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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