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124056 NOXO1

124056

NOXO1

NADPH oxidase organizer 1

protein-coding

Homo sapiens

基因描述

Type Description
Definition NADPH oxidase organizer 1

研究结论

Date Results Publications
2019-03-09 10:13:00 Tyrosine kinase substrate (Tks) proteins, analogous to the related proteins p47(phox), p40(phox) and NoxO1, also facilitate local generation of reactive oxygen species which aid in signaling at invadopodia and/or podosomes to promote their activity. As their name suggests, Tks adaptor proteins are substrates for tyrosine kinases, especially Src. [review] 29311151
2018-06-09 11:25:00 PEDF protects human glomerular mesangial cells from diabetes-derived oxidative stress via NOXO1- iNOS suppression. 28944893
2017-08-12 12:10:00 Data from pull-down assay between the Noxo1 and Noxa1 showed that the SH3 domains (Noxa1) is responsible for interaction with Noxo1 C-terminal tail harboring proline rich region. 28625920
2014-09-20 13:05:00 TNF-alpha/TNFR1 signaling promotes gastric tumorigenesis through induction of Noxo1 and Gna14 in tumor cells. 23975421
2013-11-23 11:58:00 Phosphorylation of Thr341 allows Noxo1 to sufficiently interact with Noxa1, an interaction that participates in Nox1 activation 23957209

名称对应

Type IDs
Synonymous P41NOX, P41NOXA, P41NOXB, P41NOXC, SH3PXD5, SNX28
Gene
UniProtKB-ID: NOXO1_HUMAN, A8K832_HUMAN
UniprotKB: Q8NFA2, A8K832
UniParc: UPI000000D8B3, UPI0000073C69, UPI0000071880, UPI00015DA907, UPI000006E194
EMBL: AF532983, AK292197, AF539796, BC015917, AB097667, AY255768, AF532985, AF532984, AY191359
Ensembl: ENSG00000196408
KO: hsa:124056
Nucleutide sequences
EMBL-CDS: AAO38665.1, AAM97927.1, AAN75141.1, AAM97926.1, BAC76711.1, AAM97925.1, AAP13479.1, AAH15917.1, BAF84886.1
Ensembl_TRS: ENST00000356120, ENST00000397280, ENST00000354249, ENST00000566005
Protein sequencees
Ensembl_PRO: ENSP00000348435, ENSP00000380450, ENSP00000456800, ENSP00000346195
RefSeq: NP_653204.1, XP_016878416.1, NP_751908.1, XP_016878417.1, NP_751907.1, NP_001254650.1, XP_005255156.1
Others
UniRef100: UniRef100_A8K832, UniRef100_Q8NFA2
UniRef90: UniRef90_Q8NFA2
UniRef50: UniRef50_Q8NFA2
UniGene: Hs.191762
CCDS: CCDS10454.1, CCDS58406.1, CCDS42101.1, CCDS10455.1

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