| Type | Description |
|---|---|
| Definition | activin receptor IIB |
| Date | Results | Publications |
|---|---|---|
| 2020-12-19 13:40:00 | Murine FSH Production Depends on the Activin Type II Receptors ACVR2A and ACVR2B. | 32270195 |
| 2020-10-24 14:06:00 | Novel ActRIIB ligand trap increases muscle mass and improves bone geometry in a mouse model of severe osteogenesis imperfecta. | 31419601 |
| 2018-02-10 11:46:00 | The current study reveals that ActRIIB activation by activin A induces muscle catabolism primarily through the activation of p38beta MAPK-mediated catabolic signalling that activates the ubiquitin-proteasome pathway and the autophagy-lysosome pathway. | 27897407 |
| 2018-01-06 12:27:00 | The endoplasmic reticulum stress stress and unfolded protein response are increased in mdx muscle. However, these processes are not distinctly improved by voluntary exercise or blocking activin receptor IIB ligands and thus do not appear to be optimal therapeutic choices for improving proteostasis in Duchenne muscular dystrophy. | 27554968 |
| 2017-09-09 12:29:00 | Data, including data from studies using transgenic mice, suggest that osteoblasts deficient in Acvr2A exhibit un-characteristic features; osteoclasts deficient in Acvr2A or Acvr2B or both appear normal. Acvr2A-deficient mice exhibit significantly increased femoral trabecular bone volume at 6 weeks of age; Acvr2B-deficient mice exhibit no significant change in any bone parameter. | 28659341 |
| Type | IDs |
|---|---|
| Synonymous | 4930516B21Rik, AI047905, ActRIIB |
| Gene |
UniProtKB-ID:
AVR2B_MOUSE
UniprotKB:
P27040
UniParc:
UPI000002A496,
UPI000002A497,
UPI0000027907,
UPI000002A498
EMBL:
BC106189,
M84120
Ensembl:
ENSMUSG00000061393
KO:
mmu:11481
|
| Nucleutide sequences |
EMBL-CDS:
AAI06190.1,
AAA37172.1
Ensembl_TRS:
ENSMUST00000165044,
ENSMUST00000215746,
ENSMUST00000035093
|
| Protein sequencees |
Ensembl_PRO:
ENSMUSP00000035093,
ENSMUSP00000150566,
ENSMUSP00000126108
RefSeq:
XP_030099886.1,
XP_006511989.1,
NP_031423.1,
XP_036010462.1,
XP_036010461.1,
NP_001300686.1,
XP_036010460.1
|
| Others |
UniRef100:
UniRef100_P27040
UniRef90:
UniRef90_P27040
UniRef50:
UniRef50_P27040
UniGene:
Mm.390239
CCDS:
CCDS23615.1,
CCDS90681.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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