| Type | Description |
|---|---|
| Definition | PHD finger protein 21B |
| Date | Results | Publications |
|---|---|---|
| 2018-04-07 11:11:00 | PHF21B constitutively activated wnt/beta-catenin signaling by transcriptionally downregulating SFRP1 and SFRP2, which promotes prostate cancer stem cell-like phenotype. | 28645312 |
| 2017-11-04 11:33:00 | PHF21b variants contribute significantly to differences in the levels of expression of this gene in several brain areas, including the hippocampus. Furthermore, using an animal model of stress, we found that Phf21b hippocampal gene expression is significantly decreased in animals resilient to chronic restraint stress when compared with non-chronically stressed animals. | 27777418 |
| 2015-09-26 13:19:00 | These data suggest that PHF21B is a novel tumor suppressor gene that can be inactivated by genetic and epigenetic mechanisms in the human cancer. | 25454821 |
| 2010-06-30 22:04:00 | Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | 20379614 |
| Type | IDs |
|---|---|
| Synonymous | BHC80L, PHF4 |
| Gene |
UniProtKB-ID:
PF21B_HUMAN,
A0A0S2Z6R3_HUMAN,
B1AHC5_HUMAN,
A0A0S2Z665_HUMAN
UniprotKB:
Q96EK2,
A0A0S2Z6R3,
B1AHC5,
A0A0S2Z665
UniParc:
UPI00003E2896,
UPI000020795B,
UPI0000072111,
UPI0001914E18
EMBL:
CH471138,
AK091480,
AK297317,
BC012187,
AK092243,
KF510604,
KU178843,
CR456448,
Z83838,
AL049760,
KU178842,
AL079301
Ensembl:
ENSG00000056487
KO:
hsa:112885
|
| Nucleutide sequences |
EMBL-CDS:
CAG30334.1,
AAH12187.1,
BAG52506.1,
EAW73366.1,
BAH12544.1,
ALQ34300.1,
BAG52373.1,
EAW73367.1,
ALQ34301.1
Gene_ORFName:
hCG_1989577
Ensembl_TRS:
ENST00000313237,
ENST00000629843,
ENST00000396103,
ENST00000403565
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000324403,
ENSP00000379410,
ENSP00000487086,
ENSP00000385053
RefSeq:
NP_612424.1,
XP_006724185.1,
NP_001271225.1,
XP_011528157.1,
NP_001129334.1,
NP_001229379.1
|
| Others |
UniRef100:
UniRef100_B1AHC5,
UniRef100_Q96EK2
UniRef90:
UniRef90_Q96EK2
UniRef50:
UniRef50_Q96EK2
UniGene:
Hs.254097
CCDS:
CCDS14061.1,
CCDS56234.1,
CCDS46727.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
{{protein.nucleotideVersion}}
Ensembl: {{protein.nucleotideEnsembl}} |
{{protein.proteinVersion}}
Ensembl: {{protein.proteinEnsembl}} |
{{uniprot}} , |
Definition: {{{protein.definition}}}Transcript Veriant:{{protein.transcriptVeriant}} Status: {{protein.status}} |
||||
| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
||||
暂无数据
| Pubmed编号 | 文献信息 | 发表日期 | 相关基因 |
|---|---|---|---|
| 27777418 |
The PHF21B gene is associated with major depression and modulates the stress response. Mol. Psychiatry M-L Wong , M Arcos-Burgos , S Liu , J I Vélez , C Yu , B T Baune , M C Jawahar , V Arolt , U Dannlowski , A Chuah , G A Huttley , R Fogarty , M D Lewis , S R Bornstein , J Licinio |
2017-07-01 | - |
| 28645312 |
J. Exp. Clin. Cancer Res. Qiji Li , Liping Ye , Wei Guo , Min Wang , Shuai Huang , Xinsheng Peng |
2017-06-23 | - |
| 28514442 |
Architecture of the human interactome defines protein communities and disease networks. Nature Edward L Huttlin , Raphael J Bruckner , Joao A Paulo , Joe R Cannon , Lily Ting , Kurt Baltier , Greg Colby , Fana Gebreab , Melanie P Gygi , Hannah Parzen , John Szpyt , Stanley Tam , Gabriela Zarraga , Laura Pontano-Vaites , Sharan Swarup , Anne E White , Devin K Schweppe , Ramin Rad , Brian K Erickson , Robert A Obar , K G Guruharsha , Kejie Li , Spyros Artavanis-Tsakonas , Steven P Gygi , J Wade Harper |
2017-05-25 | - |
| 26871637 |
Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing. Cell Xinping Yang , Jasmin Coulombe-Huntington , Shuli Kang , Gloria M Sheynkman , Tong Hao , Aaron Richardson , Song Sun , Fan Yang , Yun A Shen , Ryan R Murray , Kerstin Spirohn , Bridget E Begg , Miquel Duran-Frigola , Andrew MacWilliams , Samuel J Pevzner , Quan Zhong , Shelly A Trigg , Stanley Tam , Lila Ghamsari , Nidhi Sahni , Song Yi , Maria D Rodriguez , Dawit Balcha , Guihong Tan , Michael Costanzo , Brenda Andrews , Charles Boone , Xianghong J Zhou , Kourosh Salehi-Ashtiani , Benoit Charloteaux , Alyce A Chen , Michael A Calderwood , Patrick Aloy , Frederick P Roth , David E Hill , Lilia M Iakoucheva , Yu Xia , Marc Vidal |
2016-02-11 |
USH1C,
PQBP1,
OPTN,
RBM5,
CDK5,
CDK7,
RABEPK,
SRRM1,
NOD1,
CD2BP2,
RBM14,
HAX1,
SLC30A9,
STK25,
SEMA4F,
SLC19A2,
CETP,
SRSF10,
SEPT9,
ALDH1L1,
RCC1,
LDB3,
AKAP10,
SEC63,
PHF21B,
HELQ,
CKB,
ERCC8,
CLCN2,
ZFYVE27,
CLPTM1,
TTC8,
C15orf40,
COL1A2,
BBS5,
ACMSD,
DNAJC19,
CPA2,
C7orf34,
CRH,
CRK,
RDH12,
MIPOL1,
ZNF688,
SLC25A10,
NKX2-5,
CTNS,
CTSD,
UPP2,
CYBB,
CYP11A1,
TSTD2,
DAO,
REM2,
DYX1C1,
DCN,
DDC,
GLIS3,
DGUOK,
DHCR7,
DMD,
E2F6,
TYMP,
EGR2,
FLCN,
EPHX1,
EYA4,
ETFA,
ETV6,
FANCC,
FANCG,
EFEMP1,
MICU2,
ZUFSP,
FCGR3A,
ABCB7,
FGA,
FGFR1,
FH,
DOLK,
KIAA0907,
ARHGEF15,
SETX,
ARHGAP26,
SPG20,
FMO3,
ETHE1,
SLC39A14,
CDK20,
SMUG1,
FXN,
FTSJ1,
MCM9,
GABRA2,
GAD1,
SUMF2,
GALT,
UNC50,
FBXO8
|
| 25454821 |
PHF21B as a candidate tumor suppressor gene in head and neck squamous cell carcinomas. Mol Oncol Fernanda Bernardi Bertonha , Mateus de Camargo Barros Filho , Hellen Kuasne , Patricia Pintor Dos Reis , Erika da Costa Prando , Juan José Augusto Moyano Muñoz , MartÃn Roffé , Glaucia Noeli Maroso Hajj , Luiz Paulo Kowalski , Claudia Aparecida Rainho , Silvia Regina Rogatto |
2015-02-01 | - |
| 20379614 |
Mol. Med. Jed E Rose , Frédérique M Behm , Tomas Drgon , Catherine Johnson , George R Uhl |
2010-03-17 | - |
| 15489334 |
Genome Res. Daniela S Gerhard , Lukas Wagner , Elise A Feingold , Carolyn M Shenmen , Lynette H Grouse , Greg Schuler , Steven L Klein , Susan Old , Rebekah Rasooly , Peter Good , Mark Guyer , Allison M Peck , Jeffery G Derge , David Lipman , Francis S Collins , Wonhee Jang , Steven Sherry , Mike Feolo , Leonie Misquitta , Eduardo Lee , Kirill Rotmistrovsky , Susan F Greenhut , Carl F Schaefer , Kenneth Buetow , Tom I Bonner , David Haussler , Jim Kent , Mark Kiekhaus , Terry Furey , Michael Brent , Christa Prange , Kirsten Schreiber , Nicole Shapiro , Narayan K Bhat , Ralph F Hopkins , Florence Hsie , Tom Driscoll , M Bento Soares , Tom L Casavant , Todd E Scheetz , Michael J Brown-stein , Ted B Usdin , Shiraki Toshiyuki , Piero Carninci , Yulan Piao , Dawood B Dudekula , Minoru S H Ko , Koichi Kawakami , Yutaka Suzuki , Sumio Sugano , C E Gruber , M R Smith , Blake Simmons , Troy Moore , Richard Waterman , Stephen L Johnson , Yijun Ruan , Chia Lin Wei , S Mathavan , Preethi H Gunaratne , Jiaqian Wu , Angela M Garcia , Stephen W Hulyk , Edwin Fuh , Ye Yuan , Anna Sneed , Carla Kowis , Anne Hodgson , Donna M Muzny , John McPherson , Richard A Gibbs , Jessica Fahey , Erin Helton , Mark Ketteman , Anuradha Madan , Stephanie Rodrigues , Amy Sanchez , Michelle Whiting , Anup Madari , Alice C Young , Keith D Wetherby , Steven J Granite , Peggy N Kwong , Charles P Brinkley , Russell L Pearson , Gerard G Bouffard , Robert W Blakesly , Eric D Green , Mark C Dickson , Alex C Rodriguez , Jane Grimwood , Jeremy Schmutz , Richard M Myers , Yaron S N Butterfield , Malachi Griffith , Obi L Griffith , Martin I Krzywinski , Nancy Liao , Ryan Morin , Ryan Morrin , Diana Palmquist , Anca S Petrescu , Ursula Skalska , Duane E Smailus , Jeff M Stott , Angelique Schnerch , Jacqueline E Schein , Steven J M Jones , Robert A Holt , Agnes Baross , Marco A Marra , Sandra Clifton , Kathryn A Makowski , Stephanie Bosak , Joel Malek , MGC Project Team |
2004-10-01 |
Ldlrap1,
Dnajc3,
Rnaset2a,
Btnl1,
Isg15,
Cyp3a41b,
Ly6c2,
Ccl21b,
Eif3j2,
Mup18,
Lrrc19,
Rcc1,
1700047I17Rik2,
Pcsk9,
Adat3,
Tdrd7,
Sco2,
Gpr153,
Pafah2,
Gm44504,
H6pd,
Adprhl2,
Gpn2,
Rusc2,
Stx12,
Ppp1r8,
Smpdl3b,
Fam46b,
Bsdc1,
Slc44a1,
Zfand2a,
Rubcn,
Kifc1,
Pifo,
C030017K20Rik,
Cbarp,
Rpl5,
Micalcl,
Atg14,
Lrrc8c,
Noc4l,
Nsun5,
Psph,
Trrap,
Mapre3,
Ube3c,
Tbc1d14,
Hscb,
Tyw1,
Emilin1,
Rab28,
Pot1a,
Parp11,
Tada3,
Tra2a,
Brk1,
Fbxl14,
Phrf1,
Plekha1,
Gm21975,
Ric8a,
Mob2,
Prkd2,
Ccp110,
Vrk3,
Grwd1,
Nlrp6,
Trim68,
Psip1,
Spred3,
Faap24,
Ints4,
Rrp8,
Unc45a,
Igflr1,
Sf3b3,
D8Ertd738e,
Usb1,
Champ1,
Smim19,
Exoc8,
Gadd45gip1,
Phkb,
Dohh,
Fam192a,
Enkd1,
Taf5l,
Zdhhc7,
Snapc2,
Ak6,
Gpat4,
Dcun1d2,
Ankrd10,
Cog4,
Hinfp,
Lars2,
Xylb,
Imp3,
Cmtm7
|
| 15146197 |
Nat. Biotechnol. Ralph Brandenberger , Henry Wei , Sally Zhang , Shirley Lei , Jaji Murage , Gregory J Fisk , Yan Li , Chunhui Xu , Rixun Fang , Karl Guegler , Mahendra S Rao , Ramumkar Mandalam , Jane Lebkowski , Lawrence W Stanton |
2004-06-01 |
CDH2,
NAALAD2,
GUSBP9,
GTF2IP4,
CDH3,
LOC100129083,
AGAP2-AS1,
ZNF316,
FRG1HP,
PRR23D2,
UBE2Q2P2,
HDAC5,
CTAGE8,
KLLN,
BCL2L11,
FAR2P2,
LOC100240735,
NFE2L3P2,
WASH1,
ATP2A1-AS1,
GS1-124K5.4,
TOM1L1,
MAGI2-AS3,
TMEM161B-AS1,
RBFADN,
ID2-AS1,
LOC100506639,
LOC100507073,
MMP25-AS1,
GMDS-AS1,
GJC1,
RPS10-NUDT3,
FXYD6-FXYD2,
HNRNPUL2-BSCL2,
SAE1,
ABCC5,
ERVK-10,
LOC100652758,
LINC00702,
HIF1A-AS1,
PTPRU,
PQBP1,
ERVK-25,
ERVS71-1,
NLGN4Y-AS1,
HOXC13-AS,
ARPC5,
ACTR2,
NUTM2B-AS1,
CTDSP2,
ARPC2,
CDH13,
NPTN-IT1,
LINC00678,
UCHL1-AS1,
ABI2,
TENM1,
RBM7,
CASC9,
RBM5,
LHFPL2,
TNK2,
LOC101927027,
LOC101927151,
LOC101927686,
DARS-AS1,
LINC01515,
LOC101929163,
CTD-2297D10.2,
LOC101929378,
NME6,
MFSD10,
C11orf98,
SPRY1,
CDKN1B,
CTD-2154B17.1,
LOC102723673,
LOC102724562,
U2AF1L5,
LOC102725191,
SNAPC5,
MYL12B,
ANAPC10,
BASP1,
RAPGEF3,
ARIH2,
ABHD15-AS1,
LINC01162,
LINC00428,
C1D,
MERTK,
ZBTB18,
UBE2E3,
NCOA2,
SEMA3C,
CIB2,
CHERP,
LOC105369971,
CEBPG
|
| 15461802 |
A genome annotation-driven approach to cloning the human ORFeome. Genome Biol. John E Collins , Charmain L Wright , Carol A Edwards , Matthew P Davis , James A Grinham , Charlotte G Cole , Melanie E Goward , Begoña Aguado , Meera Mallya , Younes Mokrab , Elizabeth J Huckle , David M Beare , Ian Dunham |
2004-01-01 |
CHKB-AS1,
HMGXB4,
TOM1,
LOC400927-CSNK1E,
SF3A1,
CACNG2,
SLC25A17,
DDX17,
RFPL3S,
RFPL3,
RFPL2,
RFPL1S,
NUP50,
TOB2,
KDELR3,
IFT27,
CDC42EP1,
DMC1,
RABL2B,
RABL2A,
CHEK2,
CHKB,
PACSIN2,
USP18,
PHF21B,
PIK3IP1,
C1QTNF6,
C22orf39,
TANGO2,
EMID1,
ANKRD54,
COMT,
ADORA2A,
CRKL,
APOBEC3D,
ZNF280B,
CRYBA4,
CRYBB1,
CRYBB2,
CRYBB3,
CSF2RB,
CSNK1E,
CCT8L2,
LINC00896,
AIFM3,
C22orf15,
HSCB,
CCDC117,
HORMAD2,
DUSP18,
C22orf42,
ENTHD1,
DNAJB7,
FAM109B,
NFAM1,
CDPF1,
GTSE1-AS1,
CYP2D6,
ADSL,
AP1B1,
TMPRSS6,
APOBEC3H,
WBP2NL,
DDT,
POLR3H,
CYB5R3,
APOBEC3A,
APOBEC3F,
EWSR1,
MORC2,
HIC2,
GRAMD4,
TTLL12,
MLC1,
KIAA0930,
PES1,
PRAME,
SEC14L2,
RBFOX2,
SEZ6L,
RASD2,
PATZ1,
SH3BP1,
TSSK2,
SDF2L1,
PPIL2,
PITPNB,
PISD,
IL17RA,
BRD1,
BCL2L13,
TFIP11,
PRR14L,
SERHL2,
XRCC6,
TMEM211,
C22orf31,
TBC1D22A,
CBY1
|
| 14702039 |
Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat. Genet. Toshio Ota , Yutaka Suzuki , Tetsuo Nishikawa , Tetsuji Otsuki , Tomoyasu Sugiyama , Ryotaro Irie , Ai Wakamatsu , Koji Hayashi , Hiroyuki Sato , Keiichi Nagai , Kouichi Kimura , Hiroshi Makita , Mitsuo Sekine , Masaya Obayashi , Tatsunari Nishi , Toshikazu Shibahara , Toshihiro Tanaka , Shizuko Ishii , Jun-ichi Yamamoto , Kaoru Saito , Yuri Kawai , Yuko Isono , Yoshitaka Nakamura , Kenji Nagahari , Katsuhiko Murakami , Tomohiro Yasuda , Takao Iwayanagi , Masako Wagatsuma , Akiko Shiratori , Hiroaki Sudo , Takehiko Hosoiri , Yoshiko Kaku , Hiroyo Kodaira , Hiroshi Kondo , Masanori Sugawara , Makiko Takahashi , Katsuhiro Kanda , Takahide Yokoi , Takako Furuya , Emiko Kikkawa , Yuhi Omura , Kumi Abe , Kumiko Kamihara , Naoko Katsuta , Kazuomi Sato , Machiko Tanikawa , Makoto Yamazaki , Ken Ninomiya , Tadashi Ishibashi , Hiromichi Yamashita , Katsuji Murakawa , Kiyoshi Fujimori , Hiroyuki Tanai , Manabu Kimata , Motoji Watanabe , Susumu Hiraoka , Yoshiyuki Chiba , Shinichi Ishida , Yukio Ono , Sumiyo Takiguchi , Susumu Watanabe , Makoto Yosida , Tomoko Hotuta , Junko Kusano , Keiichi Kanehori , Asako Takahashi-Fujii , Hiroto Hara , Tomo-o Tanase , Yoshiko Nomura , Sakae Togiya , Fukuyo Komai , Reiko Hara , Kazuha Takeuchi , Miho Arita , Nobuyuki Imose , Kaoru Musashino , Hisatsugu Yuuki , Atsushi Oshima , Naokazu Sasaki , Satoshi Aotsuka , Yoko Yoshikawa , Hiroshi Matsunawa , Tatsuo Ichihara , Namiko Shiohata , Sanae Sano , Shogo Moriya , Hiroko Momiyama , Noriko Satoh , Sachiko Takami , Yuko Terashima , Osamu Suzuki , Satoshi Nakagawa , Akihiro Senoh , Hiroshi Mizoguchi , Yoshihiro Goto , Fumio Shimizu , Hirokazu Wakebe , Haretsugu Hishigaki , Takeshi Watanabe , Akio Sugiyama , Makoto Takemoto , Bunsei Kawakami , Masaaki Yamazaki , Koji Watanabe , Ayako Kumagai , Shoko Itakura , Yasuhito Fukuzumi , Yoshifumi Fujimori , Megumi Komiyama , Hiroyuki Tashiro , Akira Tanigami , Tsutomu Fujiwara , Toshihide Ono , Katsue Yamada , Yuka Fujii , Kouichi Ozaki , Maasa Hirao , Yoshihiro Ohmori , Ayako Kawabata , Takeshi Hikiji , Naoko Kobatake , Hiromi Inagaki , Yasuko Ikema , Sachiko Okamoto , Rie Okitani , Takuma Kawakami , Saori Noguchi , Tomoko Itoh , Keiko Shigeta , Tadashi Senba , Kyoka Matsumura , Yoshie Nakajima , Takae Mizuno , Misato Morinaga , Masahide Sasaki , Takushi Togashi , Masaaki Oyama , Hiroko Hata , Manabu Watanabe , Takami Komatsu , Junko Mizushima-Sugano , Tadashi Satoh , Yuko Shirai , Yukiko Takahashi , Kiyomi Nakagawa , Koji Okumura , Takahiro Nagase , Nobuo Nomura , Hisashi Kikuchi , Yasuhiko Masuho , Riu Yamashita , Kenta Nakai , Tetsushi Yada , Yusuke Nakamura , Osamu Ohara , Takao Isogai , Sumio Sugano |
2004-01-01 |
Slc9a8,
Nefm,
Hfe2,
AKT3,
ZBTB11-AS1,
LOC100034248,
PDZK1P1,
DDTL,
LOC100049716,
ACOT8,
GNPDA1,
ZBTB33,
GTF2IP4,
POM121C,
ZSCAN30,
SRA1,
SNORD123,
UCKL1-AS1,
ZGLP1,
LOC100125918,
LINC00322,
LOC100127940,
HECW1-IT1,
LOC100127955,
LOC100127972,
LOC100127974,
FAM229A,
LOC100128076,
STAU2-AS1,
LOC100128164,
TMPO-AS1,
LOC100128219,
LOC100128239,
LOC100128253,
TNK2-AS1,
DNM1P35,
LOC100128288,
DLG5-AS1,
LOC100128310,
TRAPPC3L,
FAM83H-AS1,
LOC100128361,
LOC100128364,
FAM225B,
LOC100128386,
LOC100128398,
ASTN2-AS1,
C1orf132,
MYHAS,
LOC100128651,
LINC00476,
SRRM2-AS1,
GPR158-AS1,
LINC01165,
VPS9D1-AS1,
FAM66B,
GATA6-AS1,
LINC01310,
LOC100128979,
LOC100128988,
LOC100129034,
SEMA3F-AS1,
UNQ6494,
LOC100129115,
KHDC1L,
LOC100129175,
MATN1-AS1,
SLC39A12-AS1,
LOC100129297,
LOC100129312,
LINC00484,
LOC100129397,
LOC100129406,
DDC-AS1,
LOC100129434,
LOC100129447,
LOC100129455,
LYRM4-AS1,
ZNF37BP,
LOC100129516,
LOC100129518,
LOC100129540,
LOC100129572,
FAM47E,
LOC100129620,
LOC100129648,
C9orf173-AS1,
LOC100129775,
SLC25A21-AS1,
PCOLCE-AS1,
SCOC-AS1,
LOC100129884,
LOC100129894,
LOC100129917,
LOC100129935,
LOC100130078,
LOC100130111,
MAPT-IT1,
MIR124-2HG
|
| 排名 | 科研单位 | 文献 |
|---|---|---|
| {{affIndex+1}} |
{{aff.value}} |
{{aff.size}} |
目前还没有研究热点单位
| 排名 | 研究人员 | 文献 |
|---|---|---|
| {{authorIndex+1}} |
{{author.value}} |
{{author.size}} |
目前还没有研究热点人员