| Type | Description |
|---|---|
| Definition | dual specificity phosphatase 10 |
| Date | Results | Publications |
|---|---|---|
| 2020-06-27 11:37:00 | Gene overexpression and knockdown demonstrated that MKP-5 could alleviate glucolipotoxicity-induced apoptosis via the endoplasmic reticulum (ER) stress and mitochondrial apoptosis pathways owing to the altered regulation of caspase family members and ER stress-related molecules. MKP-5 is a main mediator for glucolipotoxicity-induced islet cell dysfunction and apoptosis, with JNK and P38 as critical downstream pathways. | 31202710 |
| 2020-05-30 11:55:00 | Study of genome-wide epigenetic changes in bronchial epithelial cells of asthmatic patients, following cells treatment with vitamin D3 and Poly (I:C)(a viral analogue) allows the identification of biologically plausible candidate genes for viral infections and asthma, such as DUSP10 and SLC44A1. | 31122150 |
| 2020-04-11 12:34:00 | High DUSP10 expression is associated with pulmonary fibrosis. | 31483681 |
| 2019-10-26 11:33:00 | Data found DUSP10 downregulated by rhinovirus (RV) infection. siRNA-mediated knockdown of DUSP10 identified a role for the protein in negatively regulating inflammatory cytokine production in response to IL-1beta alone and in combination with RV, without any effect on RV replication. This study identifies DUSP10 as an important regulator of airway inflammation in respiratory viral infection. | 30333178 |
| 2018-12-22 10:12:00 | Our findings uncover novel associations of progressive supranuclear palsy with SLCO1A2 (rs11568563) and DUSP10 (rs6687758) variants | 29986742 |
| Type | IDs |
|---|---|
| Synonymous | MKP-5, MKP5 |
| Gene |
UniProtKB-ID:
DUS10_HUMAN
UniprotKB:
Q9Y6W6
UniParc:
UPI000003473B,
UPI0000070C36
EMBL:
BC031405,
BC063826,
CH471100,
AF179212,
AK022513,
AL590966,
AB026436,
BC020608
Ensembl:
ENSG00000143507
KO:
hsa:11221
|
| Nucleutide sequences |
EMBL-CDS:
EAW93285.1,
BAB14070.1,
AAH20608.1,
AAH63826.1,
EAW93287.1,
EAW93286.1,
BAA81668.1,
EAW93283.1,
AAH31405.1,
AAD51857.1
Ensembl_TRS:
ENST00000366899
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000355866
RefSeq:
XP_016855636.1,
NP_009138.1
|
| Others |
UniRef100:
UniRef100_Q9Y6W6
UniRef90:
UniRef90_Q9Y6W6
UniRef50:
UniRef50_Q9Y6W6
UniGene:
Hs.497822,
Hs.732301
CCDS:
CCDS1528.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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