Epigenome-wide effects of vitamin D on asthma bronchial epithelial cells.

Epigenetics. 2019 Sep;14(9):844-849. doi:10.1080/15592294.2019.1622993. Epub 2019 Jun 03

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Vitamin D is a nutrient and a hormone with multiple effects on immune regulation and respiratory viral infections, which can worsen asthma and lead to severe asthma exacerbations. We set up a complete experimental and analytical pipeline for ATAC-Seq and RNA-Seq to study genome-wide epigenetic changes in human bronchial epithelial cells of asthmatic subjects, following treatment of these cells with calcitriol (vitamin D3) and Poly (I:C)(a viral analogue). This approach led to the identification of biologically plausible candidate genes for viral infections and asthma, such as DUSP10 and SLC44A1.

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Epigenome-wide effects of vitamin D on asthma bronchial epithelial cells.

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