| Type | Description |
|---|---|
| Definition | tumor suppressor region 4 |
| Date | Results | Publications |
|---|---|---|
| 2018-05-05 10:19:00 | Results show that TSP4 regulates Ca2+ homeostasis in primary sensory neurons by affecting Ca2+ influx and buffering, including SERCA and PMCA, via signaling after binding to Cavalpha2delta1. Elevated TSP4 expression may be a key factor that disrupts Ca2+ homeostasis after neuronal injury, and may serve as a valuable target for treatment of neuropathic pain. | 28232180 |
| 2017-10-14 12:59:00 | Study found that in endothelial cells thrombospondin-4 (TSP-4), a secreted extracellular matrix protein, is upregulated in response to TGF-beta1 and mediates the effects of TGF-beta1 on angiogenesis. | 28481870 |
| 2016-11-19 11:14:00 | a TSP4/Cavalpha2delta1-dependent pathway activated by TSP4 or peripheral nerve injury promotes exaggerated presynaptic excitatory input and evoked sensory neuron hyperexcitability and excitatory synaptogenesis. | 27129212 |
| 2015-05-30 11:12:00 | TSP-4 regulates the composition of the extracellular matrix at tendons and muscles, and the its absence alters the organization, composition and physiological functions of these tissues. | 24589453 |
| Type | IDs |
|---|