Thrombospondin-4 mediates TGF-β-induced angiogenesis.
Oncogene. 2017 Sep 07;36(36):5189-5198. Epub 2017 May 08
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摘要
animals. Injections of an inhibitor of TGF-β1 signaling SB-431542 also decreased the weights of tumors and cancer angiogenesis. Our results from in vivo angiogenesis models and cultured EC document that TSP-4 mediates upregulation of angiogenesis by TGF-β1. Upregulation of pro-angiogenic TSP-4 and selective effects of TSP-4 on EC may contribute to stimulation of tumor growth by TGF-β despite the inhibition of cancer cell proliferation.
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原始数据
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文献解读
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