| Type | Description |
|---|---|
| Definition | proline rich nuclear receptor coactivator 1 |
| Date | Results | Publications |
|---|---|---|
| 2019-10-05 10:28:00 | PNRC1 ablates the enhanced proliferation triggered by established oncogenes such as RAS and MYC These observations uncover a previously undescribed mechanism of tumor suppression, whereby the cytoplasmic decapping machinery is hauled within nucleoli, tightly regulating ribosomal RNA maturation. | 30373810 |
| 2010-01-21 00:00:00 | Functional analysis of the 5' flanking region of the human PNRC gene by deletion mutagenesis, transient transfection and luciferase assays revealed that the -123/+27 region is the minimal promoter of the human PNRC gene. | 18281297 |
| 2010-01-21 00:00:00 | RFX1 specifically bind to promoter region and negatively regulate the transcription of the human PNRC gene. | 19334528 |
| 2010-01-21 00:00:00 | PNRC and Grb2, by interacting with each other, can suppress nuclear receptor-mediated regulation and growth factor-mediated regulation in human breast tissue | 15122321 |
| 2010-01-21 00:00:00 | Three human PNRC splicing variants designated PNRC1c, PNRC1d and PNRC1f, are identified. | 18703122 |
| Type | IDs |
|---|---|
| Synonymous | B4-2, PNAS-145, PROL2, PRR2 |
| Gene |
UniProtKB-ID:
PNRC1_HUMAN
UniprotKB:
Q12796
UniParc:
UPI00029DB209,
UPI0000052C62
EMBL:
CH471051,
BC018112,
AL353135,
AK312665,
AY303779,
U03105
Ensembl:
ENSG00000146278
KO:
hsa:10957
|
| Nucleutide sequences |
EMBL-CDS:
EAW48564.1,
EAW48563.1,
AAH18112.1,
AAA85576.1,
BAG35547.1,
AAP76184.1
Ensembl_TRS:
ENST00000336032
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000336931
RefSeq:
NP_006804.1
|
| Others |
UniRef100:
UniRef100_Q12796
UniRef90:
UniRef90_Q12796
UniRef50:
UniRef50_Q12796
UniGene:
Hs.75969
CCDS:
CCDS5018.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
{{protein.nucleotideVersion}}
Ensembl: {{protein.nucleotideEnsembl}} |
{{protein.proteinVersion}}
Ensembl: {{protein.proteinEnsembl}} |
{{uniprot}} , |
Definition: {{{protein.definition}}}Transcript Veriant:{{protein.transcriptVeriant}} Status: {{protein.status}} |
||||
| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
{{conservedDomain.comments == '' || conservedDomain.comments == null ? "-" : conservedDomain.comments }} |
||||
暂无数据
| Pubmed编号 | 文献信息 | 发表日期 | 相关基因 |
|---|---|---|---|
| 30833792 |
Nat. Immunol. Philipp Hubel , Christian Urban , Valter Bergant , William M Schneider , Barbara Knauer , Alexey Stukalov , Pietro Scaturro , Angelika Mann , Linda Brunotte , Heinrich H Hoffmann , John W Schoggins , Martin Schwemmle , Matthias Mann , Charles M Rice , Andreas Pichlmair |
2019-04-01 | - |
| 30373810 |
Tumor suppressor PNRC1 blocks rRNA maturation by recruiting the decapping complex to the nucleolus. EMBO J. Marco Gaviraghi , Claudia Vivori , Yerma Pareja Sanchez , Francesca Invernizzi , Angela Cattaneo , Benedetta Maria Santoliquido , Michela Frenquelli , Simona Segalla , Angela Bachi , Claudio Doglioni , Vicent Pelechano , Davide Cittaro , Giovanni Tonon |
2018-12-03 | - |
| 30021884 |
Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei. Mol Cell Proteomics Domenico Fasci , Hugo van Ingen , Richard A Scheltema , Albert J R Heck |
2018-10-01 | - |
| 28514442 |
Architecture of the human interactome defines protein communities and disease networks. Nature Edward L Huttlin , Raphael J Bruckner , Joao A Paulo , Joe R Cannon , Lily Ting , Kurt Baltier , Greg Colby , Fana Gebreab , Melanie P Gygi , Hannah Parzen , John Szpyt , Stanley Tam , Gabriela Zarraga , Laura Pontano-Vaites , Sharan Swarup , Anne E White , Devin K Schweppe , Ramin Rad , Brian K Erickson , Robert A Obar , K G Guruharsha , Kejie Li , Spyros Artavanis-Tsakonas , Steven P Gygi , J Wade Harper |
2017-05-25 | - |
| 26496610 |
A human interactome in three quantitative dimensions organized by stoichiometries and abundances. Cell Marco Y Hein , Nina C Hubner , Ina Poser , Jürgen Cox , Nagarjuna Nagaraj , Yusuke Toyoda , Igor A Gak , Ina Weisswange , Jörg Mansfeld , Frank Buchholz , Anthony A Hyman , Matthias Mann |
2015-10-22 |
Cep85l,
Rcc1,
Zbtb48,
Bsdc1,
Kifc1,
Ccp110,
Ints4,
Slc6a8,
Cenpi,
Nup107,
Xpo1,
Fbxw11,
Tubg1,
Csnk1d,
Bap1,
Ptpn23,
Tecpr2,
Slain1,
Ankrd28,
Prkaa1,
Espl1,
Gbf1,
Cdc20,
Cenpf,
Trip11,
Mbd5,
Kif22,
Dut,
Srsf1,
Actb,
Spred2,
Akt2,
Mta1,
Tgs1,
Pip4k2c,
Ankfy1,
Apc,
Ar,
Rhoa,
Atp2a2,
Atp5a1,
Atp7a,
Cep131,
Bach1,
Bcl7c,
Bmpr1a,
Brca1,
Bub1,
Bub1b,
C1qbp,
Anxa2,
Calu,
Cbx1,
Cbx4,
Cct2,
Cct3,
Cct4,
Cct7,
Cct8,
Cd2ap,
Cdk1,
Cdc37,
Cdh1,
Chek1,
Cit,
Copa,
Crebbp,
Cry1,
Csk,
Smc3,
Dctn1,
Ddb1,
Cdk2ap1,
Mapre1,
Ect2,
Eef1a1,
Eif3a,
Mark2,
Evpl,
Ewsr1,
Wdr5,
Dclre1b,
Fbl,
Fgfr1,
Flot1,
Flot2,
B4galt1,
Gnb1,
Gspt1,
Hdac6,
Herc2,
Hsf1,
Hsph1,
Elavl1,
Id2,
Cyr61,
Cep250,
Insr,
Eif3e
|
| 26186194 |
The BioPlex Network: A Systematic Exploration of the Human Interactome. Cell Edward L Huttlin , Lily Ting , Raphael J Bruckner , Fana Gebreab , Melanie P Gygi , John Szpyt , Stanley Tam , Gabriela Zarraga , Greg Colby , Kurt Baltier , Rui Dong , Virginia Guarani , Laura Pontano Vaites , Alban Ordureau , Ramin Rad , Brian K Erickson , Martin Wühr , Joel Chick , Bo Zhai , Deepak Kolippakkam , Julian Mintseris , Robert A Obar , Tim Harris , Spyros Artavanis-Tsakonas , Mathew E Sowa , Pietro De Camilli , Joao A Paulo , J Wade Harper , Steven P Gygi |
2015-07-16 | - |
| 25737280 |
Control of a neuronal morphology program by an RNA-binding zinc finger protein, Unkempt. Genes Dev. Jernej Murn , Kathi Zarnack , Yawei J Yang , Omer Durak , Elisabeth A Murphy , Sihem Cheloufi , Dilenny M Gonzalez , Marianna Teplova , Tomaž Curk , Johannes Zuber , Dinshaw J Patel , Jernej Ule , Nicholas M Luscombe , Li-Huei Tsai , Christopher A Walsh , Yang Shi |
2015-03-01 |
Sf3b3,
Pls3,
Xpo1,
Slc38a1,
Rrn3,
Hat1,
Ogt,
Foxp1,
Atp6v1h,
Pnrc1,
Ppp1r15b,
Pkn2,
Rap1a,
Acat1,
Cse1l,
Abcb7,
Actb,
Prdx3,
Ap1g1,
Arf1,
Arf4,
Arf5,
Arhgap5,
Atp2a2,
Atp5a1,
Atpif1,
Phb2,
Birc6,
Calm1,
Calm2,
Calm3,
Ctnna1,
Ctnnb1,
Cbx3,
Cbx5,
Cct4,
Cct5,
Cct8,
Cdc42,
Copa,
Cox5a,
Cox7a2,
Dpysl2,
Csnk2b,
Ctsb,
Dhx15,
Ddx5,
Dync1h1,
Dst,
Mapre1,
Eef1a1,
Eef2,
Eif3a,
Eif4a1,
Eif4a2,
Eif4g2,
Gdi1,
Gdi2,
Gfpt1,
Ggps1,
Gls,
Glud1,
Rack1,
Pdia3,
H3f3b,
Hdac2,
Hint1,
Hmgcr,
Hn1,
Hnrnpab,
Hnrnpl,
Hspd1,
Hsp90ab1,
Hsp90aa1,
Hspa4,
Hspa9,
Hspe1,
Id3,
Kpnb1,
Eif3e,
Itgb1,
Itm2b,
Kpna4,
Kpna6,
Kras,
Ldha,
Nup155,
Matr3,
Mcl1,
Msh6,
Laptm4a,
Nap1l4,
Ncl,
Nfib,
Ogdh,
Pdcd4,
Slc25a3,
Plaa,
Ppp1cb
|
| 24778252 |
TRIM65 regulates microRNA activity by ubiquitination of TNRC6. Proc Natl Acad Sci U S A Shitao Li , Lingyan Wang , Bishi Fu , Michael A Berman , Alos Diallo , Martin E Dorf |
2014-05-13 | - |
| 21900206 |
A directed protein interaction network for investigating intracellular signal transduction. Sci Signal Arunachalam Vinayagam , Ulrich Stelzl , Raphaele Foulle , Stephanie Plassmann , Martina Zenkner , Jan Timm , Heike E Assmus , Miguel A Andrade-Navarro , Erich E Wanker |
2011-09-06 |
KCNE3,
HDAC6,
PDCD6IP,
ZNF605,
TOM1L1,
HMGXB4,
RANBP9,
RWDD2B,
SNUPN,
TSSC4,
ARPC3,
ACTR1B,
CDH13,
CEBPZ,
RBM5,
CDK4,
CDK5,
TRIM13,
EIF1,
DDX39A,
HNRNPR,
RABEPK,
SPRY2,
CDKN1A,
CDK2AP2,
LOC400927-CSNK1E,
RGS19,
CDKN2B,
DSCR3,
IKZF1,
NPM3,
TUBA1B,
TUBB3,
RACK1,
PIAS3,
NDC80,
YAP1,
CDIPT,
TUBGCP3,
TIMM17A,
TAB1,
FST,
STK25,
DEAF1,
KAT5,
GLRX3,
DCTN2,
PRDX4,
RABAC1,
DPYSL4,
CCT7,
CCT4,
DRAP1,
CENPB,
TXNIP,
NPRL2,
GNB5,
CERS1,
CFL1,
MGEA5,
PLK4,
RAI1,
GIPC1,
ZNF266,
UTP14A,
PGRMC1,
RAB10,
YIF1A,
JTB,
GADD45G,
AFG3L2,
C11orf58,
HNRNPA0,
PNRC1,
ADIRF,
COPS6,
IMMT,
SF3B2,
KIF2C,
RAB31,
ADAP1,
PIM2,
RCC1,
NUDT21,
SNRNP35,
CHD3,
STMN2,
HSF2BP,
SPACA9,
RPP14,
FGFR1OP,
FAF1,
ZWINT,
CHGA,
CDC37,
CHGB,
KAT7,
C14orf1,
NUDT5
|
| 21873635 |
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Brief. Bioinformatics Pascale Gaudet , Michael S Livstone , Suzanna E Lewis , Paul D Thomas |
2011-09-01 | - |
| 排名 | 科研单位 | 文献 |
|---|---|---|
| {{affIndex+1}} |
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| 排名 | 研究人员 | 文献 |
|---|---|---|
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