| Type | Description |
|---|---|
| Definition | ubiquitin specific peptidase 20 |
| Date | Results | Publications |
|---|---|---|
| 2021-02-06 13:50:00 | The Deubiquitinating Enzyme USP20 Regulates the TNFalpha-Induced NF-kappaB Signaling Pathway through Stabilization of p62. | 32354117 |
| 2020-05-09 12:29:00 | Study revealed the molecular basis for the weak binding of USP20 N-terminal zinc-finger ubiquitin binding domain (ZnF-UBP) to mono-ubiquitin and poly-ubiquitin. The solution structure of USP20 ZnF-UBP domain consists of a central beta-sheet with either one alpha-helix or two alpha-helices packed on each side of the sheet. The overall structure of USP20 ZnF-UBP domain is stabilized by three coordinated zinc ions. | 31278784 |
| 2019-09-07 10:54:00 | USP20 is a positive regulator of beta-catenin in cancer cell migration, invasion and tumor growth in vivo. Mechanistically, USP20 deubiquitinates and stabilizes beta-catenin and is a potential biomarker for predicting chemoresistance in cancer. | 29867130 |
| 2019-02-16 10:36:00 | our results demonstrate a role of the USP20 deubiquitinating enzyme in acting as a critical regulator of ULK1 and show a novel mechanism of the autophagy process in terms of ULK1 stability. | 29487085 |
| 2017-05-13 17:28:00 | USP20 regulates actin cytoskeleton organization and cell migration in a manner dependent on ERK3 expression. The results identify USP20 as a bona fide regulator of ERK3 stability and physiological functions. | 28167606 |
| Type | IDs |
|---|---|
| Synonymous | LSFR3A, VDU2, hVDU2 |
| Gene |
UniProtKB-ID:
UBP20_HUMAN
UniprotKB:
Q9Y2K6
UniParc:
UPI000013D050
EMBL:
CH471090,
Y17459,
BC039593,
AL158207,
AY074877,
AB023220,
Y17457
Ensembl:
ENSG00000136878
KO:
hsa:10868
|
| Nucleutide sequences |
EMBL-CDS:
CAB44350.1,
AAL79676.1,
EAW87914.1,
BAA76847.2,
AAH39593.1,
CAB44352.1
Ensembl_TRS:
ENST00000372429,
ENST00000315480,
ENST00000358355
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000361506,
ENSP00000351122,
ENSP00000313811
RefSeq:
NP_001103773.2,
XP_005251722.1,
XP_024303158.1,
XP_024303157.1,
NP_001008563.2,
XP_011516463.1,
NP_006667.3,
XP_011516464.1
|
| Others |
UniRef100:
UniRef100_Q9Y2K6
UniRef90:
UniRef90_Q9Y2K6
UniRef50:
UniRef50_Q9Y2K6
UniGene:
Hs.5452
CCDS:
CCDS43892.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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