| Type | Description |
|---|---|
| Definition | protein phosphatase 1 regulatory subunit 13 like |
| Date | Results | Publications |
|---|---|---|
| 2020-12-12 13:24:00 | A previously identified apoptosis inhibitor iASPP confers resistance to chemotherapeutic drugs by suppressing senescence in cancer cells. | 32005663 |
| 2020-06-06 13:35:00 | Study revealed increased iASPP and DeltaNp63 expression in cutaneous squamous cell carcinoma (cSCC) clinical samples, but also highlighted a significant alteration of iASPP cellular localization, with consequent deregulation of its function. Data suggest that while direct effects of iASPP and p63 upon each other's expression are maintained in cSCC, epigenetic dysregulation of the feedback loop occurs at the microRNA le... | 30710576 |
| 2020-04-04 11:12:00 | iASPP inhibits p53 through a distinct surface overlapping the E6 footprint, opening prospects for p53-targeting precision medicine to improve cancer therapy. | 31395738 |
| 2020-02-29 10:48:00 | iASPP regulates growth and the cellular responses towards oxidative stress in choriocarcinoma cells. Its overexpression is advantageous to the pathogenesis of gestational trophoblastic disease. | 31615473 |
| 2020-02-22 11:39:00 | These results suggest iASPP may play an important role in progression and aggressive behavior of head and neck squamous cell carcinoma (HNSCC) and may be an efficient chemotherapeutic target for the treatment of HNSCC. | 31601301 |
| Type | IDs |
|---|---|
| Synonymous | IASPP, NKIP1, RAI, RAI4 |
| Gene |
UniProtKB-ID:
IASPP_HUMAN,
A0A024R0Q5_HUMAN
UniprotKB:
Q8WUF5,
A0A024R0Q5
UniParc:
UPI00001400F1
EMBL:
CH471126,
BC032298,
AJ888472,
AY869712,
BC020589,
DQ314886,
AF078036,
BC064913,
BC001475,
AF078037
Ensembl:
ENSG00000104881
KO:
hsa:10848
|
| Nucleutide sequences |
EMBL-CDS:
AAH01475.1,
CAI60219.1,
AAH64913.1,
ABC40745.1,
AAH32298.1,
AAD27004.1,
AAH20589.1,
AAD27005.1,
AAW51146.1,
EAW57345.1,
EAW57343.1
Gene_ORFName:
hCG_1776776
Ensembl_TRS:
ENST00000418234,
ENST00000360957
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000354218,
ENSP00000403902
RefSeq:
NP_001135974.1,
XP_016881668.1,
XP_016881666.1,
NP_006654.2,
XP_016881667.1
|
| Others |
UniRef100:
UniRef100_Q8WUF5
UniRef90:
UniRef90_Q8WUF5
UniRef50:
UniRef50_Q8WUF5
UniGene:
Hs.466937
CCDS:
CCDS33050.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Location | {{protein.contigId}} ( {{protein.positionStart}}..{{protein.positionEnd}} , {{protein.orientation}} ) | |||||||
| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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