AKAP95 Organizes a Nuclear Microdomain to Control Local cAMP for Regulating Nuclear PKA.
Cell Chem Biol. 2019 Jun 20;26(6):885-891.e4. Epub 2019 Apr 11
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摘要
Contrary to the classic model of protein kinase A residing outside of the nucleus, we identify a nuclear signaling complex that consists of AKAP95, and PDE4D5 and show that it forms a functional cyclic AMP (cAMP) signaling microdomain. Locally generated cAMP can accumulate within the vicinity of this complex; however, when cAMP is generated at the plasma membrane, PDE4 serves as a local sink and PDE3 as a barrier to prevent accumulation of cAMP within the microdomain as a means of controlling activation of tethered nuclear © 2019 Elsevier Ltd. All rights reserved.
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基因功能
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原始数据
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文献解读
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