| Type | Description |
|---|---|
| Definition | TRAF family member associated NFKB activator |
| Date | Results | Publications |
|---|---|---|
| 2021-03-06 13:30:00 | UBAC1/KPC2 Regulates TLR3 Signaling in Human Keratinocytes through Functional Interaction with the CARD14/CARMA2sh-TANK Complex. | 33316896 |
| 2020-12-19 13:41:00 | CARD14/CARMA2sh and TANK differentially regulate poly(I:C)-induced inflammatory reaction in keratinocytes. | 31486084 |
| 2020-06-06 13:37:00 | SNP rs197273 in TANK is associated both with gene expression and regional methylation. Neuroimaging studies among up to 1896 adolescents reveal that TANK is involved in the control of brain activity in areas of aversive interoceptive processing, including the insular cortex. TANK is associated with enhanced aversive emotional processing that better protects from the establishment of alcohol drinking behavior. | 30721969 |
| 2017-08-12 10:16:00 | Therefore, Seneca Valley virus suppressed antiviral interferon production to escape host antiviral innate immune responses by cleaving host adaptor molecules MAVS, TRIF, and TANK by its 3C protease. | 28566380 |
| 2017-07-15 11:40:00 | Data suggest that Encephalomyocarditis virus 3C protease cleaves TANK and disrupts the TANK-TBK1-IKKepsilon-IRF3 complex, resulting in reduction in IRF3 phosphorylation and type I interferon production. (TANK = TRAF family member associated NFKB activator; TBK1 = TANK binding kinase 1; IKKepsilon = inhibitor of nuclear factor kappa B kinase subunit epsilon; IRF3 = interferon regulatory factor 3) | 28487378 |
| Type | IDs |
|---|---|
| Synonymous | I-TRAF, ITRAF, TRAF2 |
| Gene |
UniProtKB-ID:
TANK_HUMAN,
B2R7S3_HUMAN,
Q6NW12_HUMAN
UniprotKB:
Q92844,
B2R7S3,
Q6NW12
UniParc:
UPI0000350807,
UPI000013D02B,
UPI00017505EE,
UPI0000F534B1,
UPI0000160C7B
EMBL:
AK313096,
AC009313,
BT009855,
BC003388,
CH471058,
U59863,
AC009299,
U63830,
BC067779
Ensembl:
ENSG00000136560
KO:
hsa:10010
|
| Nucleutide sequences |
EMBL-CDS:
AAC50770.1,
AAH03388.1,
AAC50681.1,
EAX11374.1,
AAP88857.1,
EAX11377.1,
EAX11375.1,
BAG35920.1,
AAH67779.1
Ensembl_TRS:
ENST00000403609,
ENST00000259075,
ENST00000392749
|
| Protein sequencees |
Ensembl_PRO:
ENSP00000259075,
ENSP00000385983,
ENSP00000376505
RefSeq:
XP_024308105.1,
XP_024308101.1,
NP_004171.2,
XP_024308103.1,
XP_016858584.1,
XP_016858585.1,
XP_016858586.1,
XP_005246264.2,
NP_001186064.1,
NP_597841.1,
XP_016858583.1,
XP_016858582.1
|
| Others |
UniRef100:
UniRef100_Q6NW12,
UniRef100_Q92844,
UniRef100_B2R7S3
UniRef90:
UniRef90_Q92844,
UniRef90_A0A2I2UKR7
UniRef50:
UniRef50_Q92844
UniGene:
Hs.132257
CCDS:
CCDS2215.1,
CCDS46436.1
|
| {{proteinIndex+1}} | mRNA | Protein | UniprotKB | Description | ||||
|---|---|---|---|---|---|---|---|---|
| Refseq |
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| Conserved domain | Region: {{conservedDomain.region == '' || conservedDomain.region == null ? "-": conservedDomain.region}} GFID: {{conservedDomain.gfid == '' || conservedDomain.gfid == null ? "-": conservedDomain.gfid}} Family: {{conservedDomain.family == '' || conservedDomain.family == null ? "-": conservedDomain.family}} CDD: {{conservedDomain.cdd}} - |
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