例如:"lncRNA", "apoptosis", "WRKY"

DIP1 plays an antiviral role against DCV infection in Drosophila melanogaster.

Biochem. Biophys. Res. Commun.2015 May 1;460(2):222-6. Epub 2015 Mar 11
Qi Zhang 1 , Liqin Zhang 1 , Xinlei Gao 1 , Shuishui Qi 1 , Zhaoxia Chang 1 , Qingfa Wu 2
Qi Zhang 1 , Liqin Zhang 1 , Xinlei Gao 1 , Shuishui Qi 1 , Zhaoxia Chang 1 , Qingfa Wu 2
+ et al

[No authors listed]

Author information
  • 1 School of Life Sciences, University of Science and Technology of China, Hefei, Anhui 230027, China.
  • 2 School of Life Sciences, University of Science and Technology of China, Hefei, Anhui 230027, China; The CAS Key Laboratory of Innate Immunity and Chronic Disease, University of Science and Technology of China, Hefei, Anhui 230027, China. Electronic address: wuqf@ustc.edu.cn.

摘要


Disconnected Interacting Protein 1 (DIP1) is a dsRNA-binding protein that participates in a wide range of cellular processes. Whether DIP1 is involved in innate immunity remains unclear. Here, DIP1 was found to play an antiviral role in S2 cells. Its antiviral action is specific for DCV infection and not for DXV infection. dip1 mutant flies are hypersensitive to DCV infection. The increased mortality in dip1 mutant flies is associated with the accumulation of DCV positive-stranded RNAs in vivo. This study demonstrated that dip1 is a novel antiviral gene that restricts DCV replication in vitro and in vivo.

KEYWORDS: Antiviral gene, DCV, DIP1, dsRNA binding domain