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36993 Dcr-2

36993

Dcr-2

Dicer-2

protein-coding

Drosophila melanogaster

基因描述

Type Description
Definition Dicer-2

研究结论

Date Results Publications
2019-07-20 12:52:00 mutating Dicer-2 results in enhanced Zika virus load and increased susceptibility to Zika virus infection 30305326
2018-07-07 12:09:00 The results uncover a novel function of Dicer-2 in activation of mRNA translation through cytoplasmic polyadenylation. 29317541
2018-06-09 12:20:00 studies indicate that the 22 amino acids at the C terminus of Loqs-PD, including an FDF-like motif, directly interact with the Hel2 subdomain of Dicer-2's helicase domain. This interaction is RNA-independent, but we find that modulation of Dicer-2 cleavage also requires dsRNA binding by Loqs-PD. 28874570
2018-05-05 10:58:00 this study used cryo-electron microscopy to solve structures of Drosophila Dicer-2 alone and in complex with blunt dsRNA. 29269422
2018-04-14 10:36:00 Loqs-PD removes the inhibitory effect of inorganic phosphate on Dicer-2 processing of blunt-end hairpin RNAs, allowing siRNA production in the presence of inorganic phosphate. 29550490

名称对应

Type IDs
Synonymous CG6493, DCR-2, DCR2, DICER, Dcr, Dcr2, Dicer, Dicer2, Dmel\CG6493, cg6493, dDcr2, dcr, dcr-2, dcr2, dic2, dicer, dicer-2, dicer2, dmDcr-2
Gene
UniProtKB-ID: A1ZAW0_DROME, A0A0B4LFK8_DROME
UniprotKB: A1ZAW0, A0A0B4LFK8
UniParc: UPI00000749CE, UPI0002B8CDA4
EMBL: BT128787, AE013599
EnsemblGenome: FBgn0034246
KO: dme:Dmel_CG6493
Nucleutide sequences
EMBL-CDS: AEL30809.1, AAF57830.2, AHN56336.1
Gene_ORFName: CG6493, Dmel_CG6493, CG6493, Dmel_CG6493
EnsemblGenome_TRS: FBtr0086904, FBtr0340217
Protein sequencees
EnsemblGenome_PRO: FBpp0086061, FBpp0309192
RefSeq: NP_523778.2, NP_001286540.1
Others
UniRef100: UniRef100_A0A0B4LFK8, UniRef100_A1ZAW0
UniRef90: UniRef90_A1ZAW0
UniRef50: UniRef50_A1ZAW0
UniGene: Dm.7764

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