Expression and localization of somatostatin receptor types 3, 4 and 5 in the wild-type, SSTR1 and SSTR1/SSTR2 knockout mouse cochlea.

Somatostatin is a peptide hormone that exerts inhibitory effects mediated through binding to specific cell surface G protein-coupled receptors, of which five distinct subtypes have been characterized. Our study performed on mouse cochlear hair cells shows the expression and localization of the three receptors in wild-type (WT), single-knockout KO) and double-knockout (DKO) mice. Similar expression were observed in the inner hair cells (IHC), outer hair cells (OHC) and supporting cells of cultivated P7 mouse organ of Corti (OC) explants as well as in cultivated cochlear neuroepithelial supporting cells (NEsc). We found differences in the expression of in WT, KO and DKO mouse cochlea, which might be explained as a compensatory effect in the cochlea after the loss of duanyu1942R1 and/or

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