Influence of very short patch mismatch repair on SOS inducing lesions after aminoglycoside treatment in Escherichia coli.
Res. Microbiol.2014 Jul-Aug ;165(6):476-80. Epub 2014 Jun 16
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摘要
Low concentrations of aminoglycosides induce the SOS response in Vibrio cholerae but not in Escherichia coli. In order to determine whether a specific factor present in E. coli prevents this induction, we developed a genetic screen where only SOS inducing mutants are viable. We identified the vsr gene coding for the Vsr protein of the very short patch mismatch repair (VSPR) pathway. The effect of mismatch repair (MMR) mutants was also studied. We propose that lesions formed upon aminoglycoside treatment are preferentially repaired by VSPR without SOS induction in E. coli and by MMR when VSPR is impaired.
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基因功能
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原始数据
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文献解读
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