Gastrin-induced proliferation involves MEK partner 1 (MP1).
In Vitro Cell. Dev. Biol. Anim.2013 Mar;49(3):162-9. doi:10.1007/s11626-013-9588-2. Epub 2013 Feb 14
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摘要
The peptide hormone gastrin is an important factor for the maintenance and homeostasis of the gastric mucosa. We show that gastrin stimulates proliferation in a dose-dependent manner in the human gastric adenocarcinoma cell line AGS-GR. Furthermore, we demonstrate that the MAPK scaffold protein MEK partner 1 (MP1) is important for gastrin-induced phosphorylation of ERK1 and ERK2 and that MP1 promotes gastrin-induced proliferation of AGS-GR cells. Our results suggest a role of MP1 in gastrin-induced cellular responses involved in proliferation and homeostasis of the gastric mucosa.
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基因功能
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原始数据
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文献解读
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