RGG repeats of PrP-like Shadoo protein bind nucleic acids.

Biochemistry. 2012 Nov 13;51(45):9029-31. doi:10.1021/bi301395w. Epub 2012 Nov 02

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摘要

Shadoo (Sho) is a central nervous system glycoprotein with characteristics similar to those of the cellular prion protein PrP(C), each containing a highly conserved hydrophobic domain (HD) and an N-terminal repeat region. Whereas PrP(C) includes histidine-containing octarepeats, the Sho region N-terminal to the HD includes tandem positively charged "RGG boxes", predicted to bind RNA. Here, we demonstrate that Sho binds DNA and RNA in vitro via this arginine-rich region.

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RGG repeats of PrP-like Shadoo protein bind nucleic acids.

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