例如:"lncRNA", "apoptosis", "WRKY"

Aiolos promotes TH17 differentiation by directly silencing Il2 expression.

Nat. Immunol.2012 Jul 01;13(8):770-7
Francisco J Quintana 1 , Hulin Jin , Evan J Burns , Meghan Nadeau , Ada Yeste , Deepak Kumar , Manu Rangachari , Chen Zhu , Sheng Xiao , John Seavitt , Katia Georgopoulos , Vijay K Kuchroo
Francisco J Quintana 1 , Hulin Jin , Evan J Burns , Meghan Nadeau , Ada Yeste , Deepak Kumar , Manu Rangachari , Chen Zhu , Sheng Xiao , John Seavitt , Katia Georgopoulos , Vijay K Kuchroo
+ et al

[No authors listed]

Author information
  • 1 Center for Neurologic Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA. fquintana@rics.bwh.harvard.edu

摘要


CD4(+) interleukin 17 (IL-17)-producing helper T cells (T(H)17 cells) are instrumental in the immune response to pathogens. However, an overactive T(H)17 response results in tissue inflammation and autoimmunity, and therefore it is important to identify the molecular mechanisms that control the development of T(H)17 cells. IL-2 suppresses such development, but how IL-2 production is actively suppressed during T(H)7 differentiation is not understood. Here we report that under T(H)17-polarizing conditions, the transcription factors and AhR upregulated the expression of Aiolos, a member of the Ikaros family of transcription factors. Using Aiolos-deficient mice, we demonstrated that Aiolos silenced the Il2 locus, promoting T(H)17 differentiation in vitro and in vivo. Thus, we have identified a module in the transcriptional program of T(H)17 cells that actively limits IL-2 production and promotes their differentiation.