Crystallization and preliminary X-ray crystallographic analysis of the catalytic domain of human dihydrouridine synthase.

Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun.2012 Mar 1;68(Pt 3):333-6. Epub 2012 Feb 22

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Dihydrouridine synthases catalyse the reduction of uridine to dihydrouridine in the D-loop and variable loop of tRNA. The human dihydrouridine synthase HsDus2L has been implicated in the development of pulmonary carcinogenesis. Here, the purification, crystallization and preliminary X-ray characterization of the HsDus2L catalytic domain are reported. The crystals belonged to space group P2(1) and contained a single molecule of HsDus2L in the asymmetric unit. A complete data set was collected to 1.9 Ã resolution using synchrotron radiation.

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Crystallization and preliminary X-ray crystallographic analysis of the catalytic domain of human dihydrouridine synthase.

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