Regulation of LYRM1 gene expression by free fatty acids, adipokines, and rosiglitazone in 3T3-L1 adipocytes.
Exp Diabetes Res. 2012;2012:820989. doi:10.1155/2012/820989. Epub 2011 Oct 26
Min Zhang 1
,
Hai-Ming Zhao
,
Zhen-Ying Qin
,
Rui Qin
,
Xiao-Hui Chen
,
Min Zhang 1
,
Hai-Ming Zhao
,
Zhen-Ying Qin
,
Rui Qin
,
Xiao-Hui Chen
,
Ya-Ping Zhao
,
Chun-Mei Zhang
,
Chun-Lin Gao
,
Chun Zhu
,
Chen-Bo Ji
,
Xin-Guo Cao
,
Xi-Rong Guo
+ et al
摘要
LYR motif containing 1 (LYRM1) is a novel gene that is abundantly expressed in the adipose tissue of obese subjects and is involved in insulin resistance. In this study, free fatty acids (FFAs) and tumor necrosis factor-α (TNF-α) are shown to upregulate LYRM1 mRNA expression in 3T3-L1 adipocytes. Conversely, resistin and rosiglitazone exert an inhibitory effect on LYRM1 mRNA expression. These results suggest that the expression of LYRM1 mRNA is affected by a variety of factors that are related to insulin sensitivity. LYRM1 may be an important mediator in the development of obesity-related insulin resistance.
