Condensin I recruitment to base damage-enriched DNA lesions is modulated by PARP1.

Condensin I is important for chromosome organization and segregation in mitosis. We previously showed that condensin I also interacts with in response to DNA damage and plays a role in single-strand break repair. However, whether condensin I physically associates with DNA damage sites and how Pduanyu371 may contribute to this process were unclear. We found that condensin I is preferentially recruited to DNA damage sites enriched for base damage. This process is dictated by Pduanyu371 through its interaction with the chromosome-targeting domain of the hCAP-D2 subunit of condensin I.

KEYWORDS: {{ getKeywords(articleDetailText.words) }}