Identification of a spatio-temporal enhancer element for the Alzheimer's amyloid precursor protein-like-1 gene in the nematode Caenorhabditis elegans.

Biosci. Biotechnol. Biochem.2010;74(12):2497-500. Epub 2010 Dec 07

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During the larva-to-adult transition of the nematode Caenorhabditis elegans, expression of the Alzheimer's amyloid precursor protein-like gene, apl-1, is temporally regulated in seam cells. This regulation requires several transcription factors, including nuclear receptor NHR-25. Here we describe a critical cis-regulatory element of apl-1 transcription. The element is conserved among Caenorhabditis sister species and is similar to nuclear receptor binding consensus.

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Identification of a spatio-temporal enhancer element for the Alzheimer's amyloid precursor protein-like-1 gene in the nematode Caenorhabditis elegans.

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