SEPT12 deficiency causes sperm nucleus damage and developmental arrest of preimplantation embryos.
Fertil. Steril.2011 Jan;95(1):363-5
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摘要
Oocytes fertilized with spermatozoa obtained from Septin 12+/- chimeric mice failed to develop beyond the morula stage after IVF and intracytoplasmic sperm injection because of significant DNA defects in the spermatozoa. Given that SEPT12 is expressed at the edge of the sperm nucleus in both humans and mice, we hypothesized the vital roles of Septin 12 in sperm head shaping, nuclear DNA condensation, and early embryonic development.
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