Ascorbic acid is a regulator of the intracellular cAMP concentration: old molecule, new functions?
FEBS Lett.2008 Oct 29;582(25-26):3614-8. Epub 2008 Oct 01
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摘要
Recently, using an animal model of Charcot-Marie-Tooth human disorder, we showed that ascorbic acid (AA) represses PMP22 gene expression by acting on intracellular cAMP concentrations. In this work, we present kinetics data on the inhibitory effect of AA upon adenylate cyclase activity. The data show that this molecule acts as a competitive inhibitor of the enzyme, a finding that opens new pharmacological avenues.
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基因功能
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原始数据
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文献解读
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