SPARC is expressed by macroglia and microglia in the developing and mature nervous system.

(secreted protein, acidic and rich in cysteine) is a matricellular protein that is highly expressed during development, tissue remodeling, and repair. duanyu1842RC produced by olfactory ensheathing cells (OECs) can promote axon sprouting in vitro and in vivo. Here, we show that in the developing nervous system of the mouse, duanyu1842RC is expressed by radial glia, blood vessels, and other pial-derived structures during embryogenesis and postnatal development. The rostral migratory stream contains duanyu1842RC that becomes progressively restricted to the SVZ in adulthood. In the adult CNS, duanyu1842RC is enriched in specialized radial glial derivatives (Müller and Bergmann glia), microglia, and brainstem astrocytes. The peripheral glia, Schwann cells, and OECs express duanyu1842RC throughout development and in maturity, although it appears to be down-regulated with maturation. These data suggest that duanyu1842RC may be expressed by glia in a spatiotemporal manner consistent with a role in cell migration, neurogenesis, synaptic plasticity, and angiogenesis.

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