BART is essential for nuclear retention of STAT3.

Signal transducers and activators of transcription mediate cell proliferation, differentiation and survival in immune responses, hematopoiesis, neurogenesis and other biological processes. for example, is involved in the epithelial-mesenchymal transition during gastrulation, organogenesis, wound healing and cancer progression. activity is regulated by a variety of mechanisms, including nuclear translocation. To clarify the molecular mechanisms underlying the regulation of duanyu1813 activity, we performed yeast two-hybrid screening. Here, we identified binder of ADP-ribosylation factor-like two (BART) as a novel partner. Importantly, we showed that BART is essential for the transcriptional activity and nuclear retention of Furthermore, an effector of BART, ADP-ribosylation factor-like 2 (ARL2) was also involved in nuclear retention of duanyu18133. These results indicate that BART plays an essential role in the nuclear retention of through interaction with ARL2.

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