例如:"lncRNA", "apoptosis", "WRKY"

Expression of endocrine genes in zebrafish larvae in response to environmental salinity.

J. Endocrinol.2007 Jun;193(3):481-91
Kazuyuki Hoshijima 1 , Shigehisa Hirose
Kazuyuki Hoshijima 1 , Shigehisa Hirose

[No authors listed]

Author information
  • 1 Department of Biological Sciences, Tokyo Institute of Technology, 4259-B-19 Nagatsuta-cho, Midori-ku, Yokohama, Kanagawa 226-8501, Japan.

摘要


We tested the capability of the endocrine system in zebrafish to respond to environmental salinity challenges during larval stages. We reveal that the zebrafish larvae have a system in which several endocrine genes, including atrial natriuretic peptide (anp), renin, prolactin, growth hormone ( gh) and parathyroid hormone 1 (pth1), respond at the transcription level to changes in environmental salinity and that the responses are gene specific. Both anp and renin are upregulated in larvae raised in dilute freshwater medium but are downregulated in concentrated medium. On the other hand, expression of prolactin and gh is strongly enhanced in the dilute medium, but shows little or no change under higher salinity conditions. Interestingly, PTH1 expression depends on Ca(2+) concentration, as observed in mammals. Thus, taken together with the advantages of a model organism, including accessibility to genetic approaches, we propose that zebrafish larvae are useful for a comprehensive study of the regulatory mechanisms of the endocrine system in ionic and osmotic homeostasis.