Identification of STAT3 as a substrate of receptor protein tyrosine phosphatase T.
[No authors listed]
摘要
Protein tyrosine phosphatase (PTP) receptor T (PTPRT) is the most frequently mutated PTP in human cancers. However, the cell signaling pathways regulated by PTPRT have not yet been elucidated. Here, we report identification of signal transducer and activator of transcription 3 as a substrate of PTPRT. Phosphorylation of a tyrosine at amino acid Y705 is essential for the function of and PTPRT specifically dephosphorylated at this position. Accordingly, overexpression of normal PTPRT in colorectal cancer cells reduced the expression of duanyu18133 target genes. These studies illuminate a mechanism regulating the duanyu18133 pathway and suggest that this signaling pathway plays an important role in colorectal tumorigenesis.
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基因功能
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原始数据
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文献解读
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