例如:"lncRNA", "apoptosis", "WRKY"

The BCL2A1 gene as a pre-T cell receptor-induced regulator of thymocyte survival.

J. Exp. Med.2005 Feb 21;201(4):603-14
Malay Mandal 1 , Christine Borowski , Teresa Palomero , Adolfo A Ferrando , Philipp Oberdoerffer , Fanyong Meng , Antonio Ruiz-Vela , Maria Ciofani , Juan-Carlos Zuniga-Pflucker , Isabella Screpanti , A Thomas Look , Stanley J Korsmeyer , Klaus Rajewsky , Harald von Boehmer , Iannis Aifantis
Malay Mandal 1 , Christine Borowski , Teresa Palomero , Adolfo A Ferrando , Philipp Oberdoerffer , Fanyong Meng , Antonio Ruiz-Vela , Maria Ciofani , Juan-Carlos Zuniga-Pflucker , Isabella Screpanti , A Thomas Look , Stanley J Korsmeyer , Klaus Rajewsky , Harald von Boehmer , Iannis Aifantis
+ et al

[No authors listed]

Author information
  • 1 Department of Medicine, Section of Rheumatology, University of Chicago, Chicago, IL 60637, USA.
全文

摘要


The pre-T cell receptor (TCR) is expressed early during T cell development and imposes a tight selection for differentiating T cell progenitors. Pre-TCR-expressing cells are selected to survive and differentiate further, whereas pre-TCR(-) cells are "negatively" selected to die. The mechanisms of pre-TCR-mediated survival are poorly understood. Here, we describe the induction of the antiapoptotic gene BCL2A1 (A1) as a potential mechanism regulating inhibition of pre-T cell death. We characterize in detail the signaling pathway involved in A1 induction and show that A1 expression can induce pre-T cell survival by inhibiting activation of caspase-3. Moreover, we show that in vitro "knockdown" of A1 expression can compromise survival even in the presence of a functional pre-TCR. Finally, we suggest that pre-TCR-induced A1 overexpression can contribute to T cell leukemia in both mice and humans.