Expression of cdc25A and cdc25B phosphatase in breast carcinoma.

BACKGROUND:Previous studies have indicated that cdc25B and cdc25A phosphatase stimulate cell cycle progression and also play a role in malignant transformation of cells. In this study, we investigated the expression of these phosphatases in breast carcinoma to elucidate their significance. METHODS:We immunohistochemically examined cdc25B and cdc25A expression in 46 cases of breast carcinoma. RESULTS:Cdc25B and cdc25A were negative or only equivocally expressed in glandular epithelial cells. In breast carcinoma, 56.5% of cases had high levels of cdc25B expression. Interestingly, the expression of cdc25B was significantly lower in cases with biologically aggressive phenotypes. The cdc25A level was high in 69.6% of cases, but we could not find any relationship between cdc25A expression and clinicopathological parameters. CONCLUSION:These results suggest that cdc25B is important especially in the early phase of breast carcinoma progression.

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