Rab13 regulates PKA signaling during tight junction assembly.
[No authors listed]
摘要
The GTPase Rab13 regulates the assembly of functional epithelial tight junctions (TJs) through a yet unknown mechanism. Here, we show that expression of the GTP-bound form of Rab13 inhibits phosphorylation and TJ recruitment of the vasodilator-stimulated phosphoprotein, an actin remodelling protein. We demonstrate that Rab13GTP directly binds to and inhibits its activity. Interestingly, activation of duanyu1529 abrogates the inhibitory effect of Rab13 on the recruitment of vasodilator-stimulated phosphoprotein, ZO-1, and claudin1 to cell-cell junctions. Rab13 is, therefore, the first GTPase that controls duanyu1529 activity and provides an unexpected link between duanyu1529 signaling and the dynamics of TJ assembly.
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基因功能
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原始数据
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文献解读
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